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Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling

Growth factor withdrawal induces rapid apoptosis via mitochondrial outer membrane permeabilization. We had previously observed that cell death of IL-3-dependent Ba/F3 cells, induced by removal of the growth factor, required the activity of the kinase GSK-3. Employing CRISPR/Cas9-mediated gene knocko...

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Detalles Bibliográficos
Autores principales:	Schubert, Florian, Rapp, Juliane, Brauns-Schubert, Prisca, Schlicher, Lisa, Stock, Kerstin, Wissler, Manuela, Weiß, Martina, Charvet, Céline, Borner, Christoph, Maurer, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913275/ https://www.ncbi.nlm.nih.gov/pubmed/29686375 http://dx.doi.org/10.1038/s41419-018-0502-4

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