ANGPTL8: An Important Regulator in Metabolic Disorders

Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still con...

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Detalles Bibliográficos
Autores principales: Luo, Mengdie, Peng, Daoquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913278/
https://www.ncbi.nlm.nih.gov/pubmed/29719529
http://dx.doi.org/10.3389/fendo.2018.00169
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author Luo, Mengdie
Peng, Daoquan
author_facet Luo, Mengdie
Peng, Daoquan
author_sort Luo, Mengdie
collection PubMed
description Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8.
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spelling pubmed-59132782018-05-01 ANGPTL8: An Important Regulator in Metabolic Disorders Luo, Mengdie Peng, Daoquan Front Endocrinol (Lausanne) Endocrinology Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8. Frontiers Media S.A. 2018-04-17 /pmc/articles/PMC5913278/ /pubmed/29719529 http://dx.doi.org/10.3389/fendo.2018.00169 Text en Copyright © 2018 Luo and Peng. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Luo, Mengdie
Peng, Daoquan
ANGPTL8: An Important Regulator in Metabolic Disorders
title ANGPTL8: An Important Regulator in Metabolic Disorders
title_full ANGPTL8: An Important Regulator in Metabolic Disorders
title_fullStr ANGPTL8: An Important Regulator in Metabolic Disorders
title_full_unstemmed ANGPTL8: An Important Regulator in Metabolic Disorders
title_short ANGPTL8: An Important Regulator in Metabolic Disorders
title_sort angptl8: an important regulator in metabolic disorders
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913278/
https://www.ncbi.nlm.nih.gov/pubmed/29719529
http://dx.doi.org/10.3389/fendo.2018.00169
work_keys_str_mv AT luomengdie angptl8animportantregulatorinmetabolicdisorders
AT pengdaoquan angptl8animportantregulatorinmetabolicdisorders

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