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Acetylome in Human Fibroblasts From Parkinson's Disease Patients

Parkinson's disease (PD) is a multifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslati...

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Autores principales: Yakhine-Diop, Sokhna M. S., Rodríguez-Arribas, Mario, Martínez-Chacón, Guadalupe, Uribe-Carretero, Elisabet, Gómez-Sánchez, Rubén, Aiastui, Ana, López de Munain, Adolfo, Bravo-San Pedro, José M., Niso-Santano, Mireia, González-Polo, Rosa A., Fuentes, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913320/
https://www.ncbi.nlm.nih.gov/pubmed/29719501
http://dx.doi.org/10.3389/fncel.2018.00097
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author Yakhine-Diop, Sokhna M. S.
Rodríguez-Arribas, Mario
Martínez-Chacón, Guadalupe
Uribe-Carretero, Elisabet
Gómez-Sánchez, Rubén
Aiastui, Ana
López de Munain, Adolfo
Bravo-San Pedro, José M.
Niso-Santano, Mireia
González-Polo, Rosa A.
Fuentes, José M.
author_facet Yakhine-Diop, Sokhna M. S.
Rodríguez-Arribas, Mario
Martínez-Chacón, Guadalupe
Uribe-Carretero, Elisabet
Gómez-Sánchez, Rubén
Aiastui, Ana
López de Munain, Adolfo
Bravo-San Pedro, José M.
Niso-Santano, Mireia
González-Polo, Rosa A.
Fuentes, José M.
author_sort Yakhine-Diop, Sokhna M. S.
collection PubMed
description Parkinson's disease (PD) is a multifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslational modifications, including protein acetylation, are involved in the molecular mechanism of PD. Acetylation of lysine proteins is a dynamic process that is modulated in PD. In this descriptive study, we characterized the acetylated proteins and peptides in primary fibroblasts from idiopathic PD (IPD) and genetic PD harboring G2019S or R1441G LRRK2 mutations. Identified acetylated peptides are modulated between individuals' groups. Although acetylated nuclear proteins are the most represented in cells, they are hypoacetylated in IPD. Results display that the level of hyperacetylated and hypoacetylated peptides are, respectively, enhanced in genetic PD and in IPD cells.
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spelling pubmed-59133202018-05-01 Acetylome in Human Fibroblasts From Parkinson's Disease Patients Yakhine-Diop, Sokhna M. S. Rodríguez-Arribas, Mario Martínez-Chacón, Guadalupe Uribe-Carretero, Elisabet Gómez-Sánchez, Rubén Aiastui, Ana López de Munain, Adolfo Bravo-San Pedro, José M. Niso-Santano, Mireia González-Polo, Rosa A. Fuentes, José M. Front Cell Neurosci Neuroscience Parkinson's disease (PD) is a multifactorial neurodegenerative disorder. The pathogenesis of this disease is associated with gene and environmental factors. Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent genetic cause of familial and sporadic PD. Moreover, posttranslational modifications, including protein acetylation, are involved in the molecular mechanism of PD. Acetylation of lysine proteins is a dynamic process that is modulated in PD. In this descriptive study, we characterized the acetylated proteins and peptides in primary fibroblasts from idiopathic PD (IPD) and genetic PD harboring G2019S or R1441G LRRK2 mutations. Identified acetylated peptides are modulated between individuals' groups. Although acetylated nuclear proteins are the most represented in cells, they are hypoacetylated in IPD. Results display that the level of hyperacetylated and hypoacetylated peptides are, respectively, enhanced in genetic PD and in IPD cells. Frontiers Media S.A. 2018-04-17 /pmc/articles/PMC5913320/ /pubmed/29719501 http://dx.doi.org/10.3389/fncel.2018.00097 Text en Copyright © 2018 Yakhine-Diop, Rodríguez-Arribas, Martínez-Chacón, Uribe-Carretero, Gómez-Sánchez, Aiastui, López de Munain, Bravo-San Pedro, Niso-Santano, González-Polo and Fuentes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yakhine-Diop, Sokhna M. S.
Rodríguez-Arribas, Mario
Martínez-Chacón, Guadalupe
Uribe-Carretero, Elisabet
Gómez-Sánchez, Rubén
Aiastui, Ana
López de Munain, Adolfo
Bravo-San Pedro, José M.
Niso-Santano, Mireia
González-Polo, Rosa A.
Fuentes, José M.
Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title_full Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title_fullStr Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title_full_unstemmed Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title_short Acetylome in Human Fibroblasts From Parkinson's Disease Patients
title_sort acetylome in human fibroblasts from parkinson's disease patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913320/
https://www.ncbi.nlm.nih.gov/pubmed/29719501
http://dx.doi.org/10.3389/fncel.2018.00097
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