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Sub-lobar dysplasia — A comprehensive evaluation with neuroimaging, magnetoencephalography and histopathology

Sublobar dysplasia, a rare cortical malformation has been defined in only 8 patients to date. It was identified on the basis of histopathological features and MRI findings. We report a right temporal sublobar dysplasia, with detailed evaluation including neuroimaging, magnetoencephalography and hist...

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Detalles Bibliográficos
Autores principales: Raghavendra, Kenchaiah, Chaitanya, Ganne, Goutham, Bhargava, Mahadevan, Anita, Mundlamuri, Ravindranadh Chowdary, Bharath, Rose Dawn, Narayannan, Mariyappa, Rao, Malla Bhaskar, Arivazhagan, Arimappamagan, Satishchandra, Parthasarthy, Sinha, Sanjib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913359/
https://www.ncbi.nlm.nih.gov/pubmed/29692965
http://dx.doi.org/10.1016/j.ebcr.2017.11.002
Descripción
Sumario:Sublobar dysplasia, a rare cortical malformation has been defined in only 8 patients to date. It was identified on the basis of histopathological features and MRI findings. We report a right temporal sublobar dysplasia, with detailed evaluation including neuroimaging, magnetoencephalography and histopathology to further characterize the pathology. Additional pathological features included a deep collateral sulcus in the basal right temporal lobe, thinned out right corticospinal tract, and bilateral asymmetric basal ganglia changes. Magnetoencephalograpy localized the seizure focus to the posterior margin of the dysplasia. Histopathological evaluation helped exclude other types of dysplasia. Similar to a previous study, the child had Engel 1a outcome.