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Yoda1 analogue (Dooku1) which antagonizes Yoda1‐evoked activation of Piezo1 and aortic relaxation
BACKGROUND AND PURPOSE: The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of these channels is otherwise limited. EXPERIMENTAL APPROACH: Yoda1 analogues were generated by synthetic chemistry. Intracellu...
Autores principales: | Evans, Elizabeth L, Cuthbertson, Kevin, Endesh, Naima, Rode, Baptiste, Blythe, Nicola M, Hyman, Adam J, Hall, Sally J, Gaunt, Hannah J, Ludlow, Melanie J, Foster, Richard, Beech, David J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913400/ https://www.ncbi.nlm.nih.gov/pubmed/29498036 http://dx.doi.org/10.1111/bph.14188 |
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