Transplant Drug Interactions and a Word of Caution for the HIV Provider. A Case Report

Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver transplant rejection in an HIV-positive recip...

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Detalles Bibliográficos
Autores principales: Hemmersbach-Miller, Marion, Berg, Carl L, Messina, Julia A, Wolfe, Cameron R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
ID Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913676/
https://www.ncbi.nlm.nih.gov/pubmed/29713654
http://dx.doi.org/10.1093/ofid/ofy070
Descripción
Sumario:Electronic medical record platforms fail to support provider alerts when a drug is discontinued. Protease inhibitors, often boosted by ritonavir or cobicistat, increase the serum concentration of calcineurin inhibitors. This case demonstrates acute liver transplant rejection in an HIV-positive recipient due to a failure to recognize the loss of protease inhibitor interaction with his immunosuppressive regimen.

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