Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach

[Image: see text] Plant homeodomain (PHD) zinc fingers are histone reader domains that are often associated with human diseases. Despite this, they constitute a poorly targeted class of readers, suggesting low ligandability. Here, we describe a successful fragment-based campaign targeting PHD finger...

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Detalles Bibliográficos
Autores principales: Amato, Anastasia, Lucas, Xavier, Bortoluzzi, Alessio, Wright, David, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913730/
https://www.ncbi.nlm.nih.gov/pubmed/29529862
http://dx.doi.org/10.1021/acschembio.7b01093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913730/
https://www.ncbi.nlm.nih.gov/pubmed/29529862
http://dx.doi.org/10.1021/acschembio.7b01093

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