Cargando…

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach

[Image: see text] Plant homeodomain (PHD) zinc fingers are histone reader domains that are often associated with human diseases. Despite this, they constitute a poorly targeted class of readers, suggesting low ligandability. Here, we describe a successful fragment-based campaign targeting PHD finger...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amato, Anastasia, Lucas, Xavier, Bortoluzzi, Alessio, Wright, David, Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913730/ https://www.ncbi.nlm.nih.gov/pubmed/29529862 http://dx.doi.org/10.1021/acschembio.7b01093

Ejemplares similares

Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains
por: Bortoluzzi, Alessio, et al.
Publicado: (2017)

Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase
por: Lucas, Xavier, et al.
Publicado: (2018)

Ectopic expression of Medicago truncatula homeodomain finger protein, MtPHD6, enhances drought tolerance in Arabidopsis
por: Quan, Wenli, et al.
Publicado: (2019)

Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions
por: Jain, Kanishk, et al.
Publicado: (2020)

Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger
por: Miller, Thomas C. R., et al.
Publicado: (2014)

Genomic basis of multiphase evolution driving divergent selection of zinc-finger homeodomain genes
por: Jang, Min-Jeong, et al.
Publicado: (2023)

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements
por: Morreale, Francesca E., et al.
Publicado: (2017)

Zinc Finger-Homeodomain Genes: Evolution, Functional Differentiation, and Expression Profiling Under Flowering-Related Treatments and Abiotic Stresses in Plants
por: Shalmani, Abdullah, et al.
Publicado: (2019)

Genome-Wide Investigation of the Zinc Finger-Homeodomain Family Genes Reveals Potential Roles in Apple Fruit Ripening
por: Zheng, Xian-bo, et al.
Publicado: (2022)

Response of phytohormone mediated plant homeodomain (PHD) family to abiotic stress in upland cotton (Gossypium hirsutum spp.)
por: Wu, Huanhuan, et al.
Publicado: (2021)

Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC
por: Tallant, Cynthia, et al.
Publicado: (2015)

Thioamide substitution to probe the hydroxyproline recognition of VHL ligands
por: Soares, Pedro, et al.
Publicado: (2018)

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening
por: Morreale, Francesca E., et al.
Publicado: (2017)

Handpicking epigenetic marks with PHD fingers
por: Musselman, Catherine A., et al.
Publicado: (2011)

Atypical histone targets of PHD fingers
por: Black, Joshua C., et al.
Publicado: (2023)

Genome-Wide Identification, Evolution and Expression Analysis of the Grape (Vitis vinifera L.) Zinc Finger-Homeodomain Gene Family
por: Wang, Hao, et al.
Publicado: (2014)

Plant homeodomain finger protein 23 inhibits autophagy and promotes apoptosis of chondrocytes in osteoarthritis
por: Li, Xiang, et al.
Publicado: (2019)

Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation
por: Estève, Pierre-Olivier, et al.
Publicado: (2014)

Functional characterization of Lilium lancifolium cold-responsive Zinc Finger Homeodomain (ZFHD) gene in abscisic acid and osmotic stress tolerance
por: Yong, Yubing, et al.
Publicado: (2021)

In silico and computational analysis of zinc finger motif-associated homeodomain (ZF-HD) family genes in chilli (Capsicum annuum L)
por: Islam, Md. Abir Ul, et al.
Publicado: (2023)

RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.
por: Frost, Julianty, et al.
Publicado: (2019)

An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23
por: Song, Daisheng, et al.
Publicado: (2019)

Identification of family-determining residues in PHD fingers
por: Slama, Patrick, et al.
Publicado: (2011)

MALE STERILITY 3 encodes a plant homeodomain‐finger protein for male fertility in soybean
por: Hou, Jingjing, et al.
Publicado: (2022)

Zinc Finger-Homeodomain Transcriptional Factors (ZHDs) in Upland Cotton (Gossypium hirsutum): Genome-Wide Identification and Expression Analysis in Fiber Development
por: Abdullah, Muhammad, et al.
Publicado: (2018)

PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma
por: Yang, Yan, et al.
Publicado: (2018)

Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-Containing Zinc Finger Proteins
por: Wang, Wei, et al.
Publicado: (2014)

Zinc Finger-Homeodomain Transcriptional Factors (ZF-HDs) in Wheat (Triticum aestivum L.): Identification, Evolution, Expression Analysis and Response to Abiotic Stresses
por: Liu, Hao, et al.
Publicado: (2021)

Structural basis of diversity and homodimerization specificity of zinc-finger-associated domains in Drosophila
por: Bonchuk, Artem, et al.
Publicado: (2021)

PHD finger proteins function in plant development and abiotic stress responses: an overview
por: Quan, Wenli, et al.
Publicado: (2023)

Zinc-finger domains in metazoans: evolution gone wild
por: Albà, M. Mar
Publicado: (2017)

Genome-wide analysis of PHD finger gene family and identification of potential miRNA and their PHD finger gene specific targets in Oryza sativa indica
por: Waziri, Aafrin, et al.
Publicado: (2020)

Genome-wide analysis and expression profiling of zinc finger homeodomain (ZHD) family genes reveal likely roles in organ development and stress responses in tomato
por: Khatun, Khadiza, et al.
Publicado: (2017)

Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
por: Coleman, Oliver D., et al.
Publicado: (2023)

Pathogen-induced binding of the soybean zinc finger homeodomain proteins GmZF-HD1 and GmZF-HD2 to two repeats of ATTA homeodomain binding site in the calmodulin isoform 4 (GmCaM4) promoter
por: Park, Hyeong Cheol, et al.
Publicado: (2007)

Insertional mutagenesis screening identifies the zinc finger homeodomain 2 (zfh2) gene as a novel factor required for embryonic leg development in Tribolium castaneum
por: Kittelmann, Maike, et al.
Publicado: (2009)

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
por: Wang, Gang G., et al.
Publicado: (2009)

The cohesin loader SCC2 contains a PHD finger that is required for meiosis in land plants
por: Wang, Hongkuan, et al.
Publicado: (2020)

Allosteric Remodelling of the Histone H3 Binding Pocket in the Pygo2 PHD Finger Triggered by Its Binding to the B9L/BCL9 Co-Factor
por: Miller, Thomas C.R., et al.
Publicado: (2010)

The Homeodomain Derived Peptide Penetratin Induces Curvature of Fluid Membrane Domains
por: Lamazière, Antonin, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_2rmgcur643bpl2gpbri2tqc3m2