Cargando…

Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis

BACKGROUND: To compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on final height. METHODS: Data derived from the Lupus Outcomes Study, a longitudinal c...

Descripción completa

Detalles Bibliográficos
Autores principales: Heshin-Bekenstein, Merav, Perl, Liat, Hersh, Aimee O., von Scheven, Emily, Yelin, Ed, Trupin, Laura, Yazdany, Jinoos, Lawson, Erica F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913867/
https://www.ncbi.nlm.nih.gov/pubmed/29688869
http://dx.doi.org/10.1186/s12969-018-0239-8
_version_ 1783316616565489664
author Heshin-Bekenstein, Merav
Perl, Liat
Hersh, Aimee O.
von Scheven, Emily
Yelin, Ed
Trupin, Laura
Yazdany, Jinoos
Lawson, Erica F.
author_facet Heshin-Bekenstein, Merav
Perl, Liat
Hersh, Aimee O.
von Scheven, Emily
Yelin, Ed
Trupin, Laura
Yazdany, Jinoos
Lawson, Erica F.
author_sort Heshin-Bekenstein, Merav
collection PubMed
description BACKGROUND: To compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on final height. METHODS: Data derived from the Lupus Outcomes Study, a longitudinal cohort of adults with SLE, was used for this cross-sectional analysis (N = 728). Participants aged 18–63 years with complete height data were included (N = 566) and were classified as cSLE if age at diagnosis was < 18 years (N = 72). The Tanner formula was used to calculate mid-parental target height. Multivariate linear regression was used to determine mean difference between final height and target height. Multivariate logistic regression was used to compare odds of substantially reduced final height, defined as > 2 SD below target height. Separate analyses were conducted for females and males to account for differences in timing of the pubertal growth spurt for each sex. RESULTS: Participants with cSLE were, on average, 2.4 cm shorter than their target height (95% CI -4, − 0.7). The adjusted odds ratio (OR) for substantially reduced final height was 3.9 (95% CI + 2.0, + 7.2, p < 0.001) as compared to participants with aSLE. Females diagnosed between 11 and 13 years were at greatest risk for substantially reduced final height, with adjusted OR of 11.2 (95% CI + 3.4, + 36.3) as compared to participants with aSLE (p < 0.001). CONCLUSIONS: cSLE is associated with shorter-than-expected final height. Onset of SLE in the pubertal period, near the time of maximum linear growth, may have a particularly significant impact on final height.
format Online
Article
Text
id pubmed-5913867
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-59138672018-04-30 Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis Heshin-Bekenstein, Merav Perl, Liat Hersh, Aimee O. von Scheven, Emily Yelin, Ed Trupin, Laura Yazdany, Jinoos Lawson, Erica F. Pediatr Rheumatol Online J Research Article BACKGROUND: To compare final height to mid-parental target height among adults with childhood-onset systemic lupus erythematosus (cSLE) versus adult-onset SLE (aSLE), and to evaluate the impact of age at SLE onset on final height. METHODS: Data derived from the Lupus Outcomes Study, a longitudinal cohort of adults with SLE, was used for this cross-sectional analysis (N = 728). Participants aged 18–63 years with complete height data were included (N = 566) and were classified as cSLE if age at diagnosis was < 18 years (N = 72). The Tanner formula was used to calculate mid-parental target height. Multivariate linear regression was used to determine mean difference between final height and target height. Multivariate logistic regression was used to compare odds of substantially reduced final height, defined as > 2 SD below target height. Separate analyses were conducted for females and males to account for differences in timing of the pubertal growth spurt for each sex. RESULTS: Participants with cSLE were, on average, 2.4 cm shorter than their target height (95% CI -4, − 0.7). The adjusted odds ratio (OR) for substantially reduced final height was 3.9 (95% CI + 2.0, + 7.2, p < 0.001) as compared to participants with aSLE. Females diagnosed between 11 and 13 years were at greatest risk for substantially reduced final height, with adjusted OR of 11.2 (95% CI + 3.4, + 36.3) as compared to participants with aSLE (p < 0.001). CONCLUSIONS: cSLE is associated with shorter-than-expected final height. Onset of SLE in the pubertal period, near the time of maximum linear growth, may have a particularly significant impact on final height. BioMed Central 2018-04-23 /pmc/articles/PMC5913867/ /pubmed/29688869 http://dx.doi.org/10.1186/s12969-018-0239-8 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Heshin-Bekenstein, Merav
Perl, Liat
Hersh, Aimee O.
von Scheven, Emily
Yelin, Ed
Trupin, Laura
Yazdany, Jinoos
Lawson, Erica F.
Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title_full Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title_fullStr Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title_full_unstemmed Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title_short Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
title_sort final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913867/
https://www.ncbi.nlm.nih.gov/pubmed/29688869
http://dx.doi.org/10.1186/s12969-018-0239-8
work_keys_str_mv AT heshinbekensteinmerav finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT perlliat finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT hershaimeeo finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT vonschevenemily finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT yelined finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT trupinlaura finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT yazdanyjinoos finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis
AT lawsonericaf finaladultheightofpatientswithchildhoodonsetsystemiclupuserythematosusacrosssectionalanalysis