First case of AML with rare chromosome translocations: a case report of twins

BACKGROUND: Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare...

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Autores principales: Wang, Lin, Sun, Yanhua, Sun, Yanli, Meng, Lingbin, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913884/
https://www.ncbi.nlm.nih.gov/pubmed/29688850
http://dx.doi.org/10.1186/s12885-018-4396-4
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author Wang, Lin
Sun, Yanhua
Sun, Yanli
Meng, Lingbin
Xu, Xin
author_facet Wang, Lin
Sun, Yanhua
Sun, Yanli
Meng, Lingbin
Xu, Xin
author_sort Wang, Lin
collection PubMed
description BACKGROUND: Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. CASE PRESENTATION: Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient’s healthy sibling as a sequencing control. CONCLUSION: This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4396-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-59138842018-04-30 First case of AML with rare chromosome translocations: a case report of twins Wang, Lin Sun, Yanhua Sun, Yanli Meng, Lingbin Xu, Xin BMC Cancer Case Report BACKGROUND: Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangements may also contribute to leukemogenesis but are less summarized. CASE PRESENTATION: Here we reported rare fusion genes ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15 in a 47-year-old AML-M4 patient with FLT3 internal tandem duplication (ITD) discovered by whole genome sequencing (WGS) using the patient’s healthy sibling as a sequencing control. CONCLUSION: This is, to our knowledge, the first case of AML with fusion gene ZNF717-ZNF37A, ZNF273-DGKA, and ZDHHC2-TTTY15. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12885-018-4396-4) contains supplementary material, which is available to authorized users. BioMed Central 2018-04-23 /pmc/articles/PMC5913884/ /pubmed/29688850 http://dx.doi.org/10.1186/s12885-018-4396-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Wang, Lin
Sun, Yanhua
Sun, Yanli
Meng, Lingbin
Xu, Xin
First case of AML with rare chromosome translocations: a case report of twins
title First case of AML with rare chromosome translocations: a case report of twins
title_full First case of AML with rare chromosome translocations: a case report of twins
title_fullStr First case of AML with rare chromosome translocations: a case report of twins
title_full_unstemmed First case of AML with rare chromosome translocations: a case report of twins
title_short First case of AML with rare chromosome translocations: a case report of twins
title_sort first case of aml with rare chromosome translocations: a case report of twins
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913884/
https://www.ncbi.nlm.nih.gov/pubmed/29688850
http://dx.doi.org/10.1186/s12885-018-4396-4
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AT menglingbin firstcaseofamlwithrarechromosometranslocationsacasereportoftwins
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