Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver

The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. I...

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Detalles Bibliográficos
Autores principales: Rauf Maksud, Agayev, Andrey Gennadiyevich, Popandopulo, Rasim Elkhan, Jafarli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913901/
https://www.ncbi.nlm.nih.gov/pubmed/29699353
http://dx.doi.org/10.5005/jp-journals-10018-1107
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author Rauf Maksud, Agayev
Andrey Gennadiyevich, Popandopulo
Rasim Elkhan, Jafarli
author_facet Rauf Maksud, Agayev
Andrey Gennadiyevich, Popandopulo
Rasim Elkhan, Jafarli
author_sort Rauf Maksud, Agayev
collection PubMed
description The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment modalities for cirrhotic liver. How to cite this article: Maksud AR, Gennadiyevich PA, Elkhan JR. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepato-Gastroenterol 2014;4(2):83-86.
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spelling pubmed-59139012018-04-25 Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver Rauf Maksud, Agayev Andrey Gennadiyevich, Popandopulo Rasim Elkhan, Jafarli Euroasian J Hepatogastroenterol Original Article The efficacy of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver was evaluated in an animal model of cirrhotic liver. Autologous stem cells were obtained from bone marrow. Transplantation was performed 1 week after surgery by introducing stem cells into the liver. Immunohistochemical staining (proliferative activity, myofibroblast activation and sinusoidal capillarization) was evaluated to assess the efficacy of transplantation. It was found that, 2 months after stem cell transplantation, the severity of perisinusoidal fibrosis, inflammation of the liver and the number of myofibroblasts were reduced. Stem cell transplantation may be one of the new treatment modalities for cirrhotic liver. How to cite this article: Maksud AR, Gennadiyevich PA, Elkhan JR. Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver. Euroasian J Hepato-Gastroenterol 2014;4(2):83-86. Jaypee Brothers Medical Publishers 2014 2014-07-28 /pmc/articles/PMC5913901/ /pubmed/29699353 http://dx.doi.org/10.5005/jp-journals-10018-1107 Text en Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Original Article
Rauf Maksud, Agayev
Andrey Gennadiyevich, Popandopulo
Rasim Elkhan, Jafarli
Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title_full Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title_fullStr Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title_full_unstemmed Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title_short Influence of Mesenchymal Stem Cells Transplantation on Regeneration Activity of Cirrhotic Liver
title_sort influence of mesenchymal stem cells transplantation on regeneration activity of cirrhotic liver
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913901/
https://www.ncbi.nlm.nih.gov/pubmed/29699353
http://dx.doi.org/10.5005/jp-journals-10018-1107
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AT rasimelkhanjafarli influenceofmesenchymalstemcellstransplantationonregenerationactivityofcirrhoticliver

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