Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...

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Detalles Bibliográficos
Autores principales: Subramaniam, Suvitha, Schmid, Christoph D., Guan, Xue Li, Mäser, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Biologic Response Modifiers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913926/
https://www.ncbi.nlm.nih.gov/pubmed/29358287
http://dx.doi.org/10.1128/AAC.01533-17
Descripción
Sumario:Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.

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