Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...

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Autores principales: Subramaniam, Suvitha, Schmid, Christoph D., Guan, Xue Li, Mäser, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Biologic Response Modifiers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913926/
https://www.ncbi.nlm.nih.gov/pubmed/29358287
http://dx.doi.org/10.1128/AAC.01533-17
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author Subramaniam, Suvitha
Schmid, Christoph D.
Guan, Xue Li
Mäser, Pascal
author_facet Subramaniam, Suvitha
Schmid, Christoph D.
Guan, Xue Li
Mäser, Pascal
author_sort Subramaniam, Suvitha
collection PubMed
description Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase.
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spelling pubmed-59139262018-05-07 Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria Subramaniam, Suvitha Schmid, Christoph D. Guan, Xue Li Mäser, Pascal Antimicrob Agents Chemother Biologic Response Modifiers Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic lethal interaction but are absent in humans. This suggests new options for drug combinations, particularly for inhibitors of targets such as P. falciparum calcineurin, cation ATPase 4, or phosphatidylinositol 4-kinase. American Society for Microbiology 2018-03-27 /pmc/articles/PMC5913926/ /pubmed/29358287 http://dx.doi.org/10.1128/AAC.01533-17 Text en Copyright © 2018 Subramaniam et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biologic Response Modifiers
Subramaniam, Suvitha
Schmid, Christoph D.
Guan, Xue Li
Mäser, Pascal
Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title_full Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title_fullStr Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title_full_unstemmed Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title_short Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria
title_sort using yeast synthetic lethality to inform drug combination for malaria
topic Biologic Response Modifiers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913926/
https://www.ncbi.nlm.nih.gov/pubmed/29358287
http://dx.doi.org/10.1128/AAC.01533-17
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