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Using Yeast Synthetic Lethality To Inform Drug Combination for Malaria

Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of the gene pairs of Plasmodium falciparum that possess orthologues in yeast that have a synthetic letha...

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Detalles Bibliográficos
Autores principales:	Subramaniam, Suvitha, Schmid, Christoph D., Guan, Xue Li, Mäser, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Biologic Response Modifiers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913926/ https://www.ncbi.nlm.nih.gov/pubmed/29358287 http://dx.doi.org/10.1128/AAC.01533-17

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