In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria

Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically relevant anaerobes was sim...

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Autores principales: Stapert, Laure, Wolfe, Cindy, Shinabarger, Dean, Marra, Andrea, Pillar, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913939/
https://www.ncbi.nlm.nih.gov/pubmed/29439961
http://dx.doi.org/10.1128/AAC.00047-18
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author Stapert, Laure
Wolfe, Cindy
Shinabarger, Dean
Marra, Andrea
Pillar, Chris
author_facet Stapert, Laure
Wolfe, Cindy
Shinabarger, Dean
Marra, Andrea
Pillar, Chris
author_sort Stapert, Laure
collection PubMed
description Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically relevant anaerobes was similar to that of tigecycline, with MIC(90) values of 1 to 8 μg/ml against Bacteroides spp., 0.5 μg/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica, 1 μg/ml against Peptostreptococcus spp., and 16 μg/ml against Clostridium perfringens.
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spelling pubmed-59139392018-05-07 In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria Stapert, Laure Wolfe, Cindy Shinabarger, Dean Marra, Andrea Pillar, Chris Antimicrob Agents Chemother Clinical Therapeutics Omadacycline (OMC), a broad-spectrum aminomethylcycline, has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections. Here, the in vitro activity of OMC against clinically relevant anaerobes was similar to that of tigecycline, with MIC(90) values of 1 to 8 μg/ml against Bacteroides spp., 0.5 μg/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica, 1 μg/ml against Peptostreptococcus spp., and 16 μg/ml against Clostridium perfringens. American Society for Microbiology 2018-03-27 /pmc/articles/PMC5913939/ /pubmed/29439961 http://dx.doi.org/10.1128/AAC.00047-18 Text en Copyright © 2018 Stapert et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Therapeutics
Stapert, Laure
Wolfe, Cindy
Shinabarger, Dean
Marra, Andrea
Pillar, Chris
In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title_full In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title_fullStr In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title_full_unstemmed In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title_short In Vitro Activities of Omadacycline and Comparators against Anaerobic Bacteria
title_sort in vitro activities of omadacycline and comparators against anaerobic bacteria
topic Clinical Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913939/
https://www.ncbi.nlm.nih.gov/pubmed/29439961
http://dx.doi.org/10.1128/AAC.00047-18
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