Visualization of murine lymph vessels using photoacoustic imaging with contrast agents

Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of sca...

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Autores principales: Nagaoka, Ryo, Tabata, Takuya, Yoshizawa, Shin, Umemura, Shin-ichiro, Saijo, Yoshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914200/
https://www.ncbi.nlm.nih.gov/pubmed/29707478
http://dx.doi.org/10.1016/j.pacs.2018.01.001
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author Nagaoka, Ryo
Tabata, Takuya
Yoshizawa, Shin
Umemura, Shin-ichiro
Saijo, Yoshifumi
author_facet Nagaoka, Ryo
Tabata, Takuya
Yoshizawa, Shin
Umemura, Shin-ichiro
Saijo, Yoshifumi
author_sort Nagaoka, Ryo
collection PubMed
description Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents.
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spelling pubmed-59142002018-04-27 Visualization of murine lymph vessels using photoacoustic imaging with contrast agents Nagaoka, Ryo Tabata, Takuya Yoshizawa, Shin Umemura, Shin-ichiro Saijo, Yoshifumi Photoacoustics Research Article Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was −1.90 dB/mm, whereas that of the fluorescence imaging was −4.45 dB/mm. The results indicate the potential of identifying sentinel lymph nodes by using PA imaging with these contrast agents. Elsevier 2018-01-31 /pmc/articles/PMC5914200/ /pubmed/29707478 http://dx.doi.org/10.1016/j.pacs.2018.01.001 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Article
Nagaoka, Ryo
Tabata, Takuya
Yoshizawa, Shin
Umemura, Shin-ichiro
Saijo, Yoshifumi
Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title_full Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title_fullStr Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title_full_unstemmed Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title_short Visualization of murine lymph vessels using photoacoustic imaging with contrast agents
title_sort visualization of murine lymph vessels using photoacoustic imaging with contrast agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914200/
https://www.ncbi.nlm.nih.gov/pubmed/29707478
http://dx.doi.org/10.1016/j.pacs.2018.01.001
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