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Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga

CONTEXT AND AIMS: Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between change...

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Autores principales: Halappa, Naveen Gowrapura, Thirthalli, Jagadisha, Varambally, Shivarama, Rao, Mukund, Christopher, Rita, Nanjundaiah, Gangadhar B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914260/
https://www.ncbi.nlm.nih.gov/pubmed/29736060
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_154_17
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author Halappa, Naveen Gowrapura
Thirthalli, Jagadisha
Varambally, Shivarama
Rao, Mukund
Christopher, Rita
Nanjundaiah, Gangadhar B.
author_facet Halappa, Naveen Gowrapura
Thirthalli, Jagadisha
Varambally, Shivarama
Rao, Mukund
Christopher, Rita
Nanjundaiah, Gangadhar B.
author_sort Halappa, Naveen Gowrapura
collection PubMed
description CONTEXT AND AIMS: Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between changes in neuropsychological test performance and serum brain-derived neurotrophic factor (BDNF) levels was also explored. MATERIALS AND METHODS: Antidepressant-naïve/antidepressant-free outpatients with depression received antidepressant medication alone (n = 23) or yoga therapy with (n = 26) or without (n = 16) antidepressants. Depression was assessed using the Hamilton Depression Rating Scale. Neuropsychological tests included digit-span forward and backward, Rey Auditory Verbal Learning Test, and Trail Making Tests (TMT-A and B). These tests were administered before and 3 months after the treatment in patients, and once in healthy comparison subjects (n = 19). STATISTICAL ANALYSIS: Baseline differences were analyzed using independent sample t-test, Chi-square, and one-way ANOVA. Paired t-test was used to analyze the change from baseline to follow-up. Pearson's correlation was used to explore the association of change between 2 variables. RESULTS: Patients had impaired performance on most neuropsychological tests. After 3 months, there was significant improvement – patients’ performance was comparable to that of healthy controls on majority of the tests. Significant inverse correlation was observed between increase in BDNF levels and improvement in TMT “A” duration in Yoga-alone group (r = −0.647; P = 0.009). CONCLUSIONS: To conclude that, Yoga therapy, alone or in combination with medications, is associated with improved neuropsychological functions and neuroplastic effects in patients with depression.
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spelling pubmed-59142602018-05-07 Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga Halappa, Naveen Gowrapura Thirthalli, Jagadisha Varambally, Shivarama Rao, Mukund Christopher, Rita Nanjundaiah, Gangadhar B. Indian J Psychiatry Original Article CONTEXT AND AIMS: Impairment in cognition is well-known in patients with major depressive disorder. This study examined the effect of yoga therapy with or without antidepressants and antidepressants alone on certain neuropsychological functions in patients with depression. Correlation between changes in neuropsychological test performance and serum brain-derived neurotrophic factor (BDNF) levels was also explored. MATERIALS AND METHODS: Antidepressant-naïve/antidepressant-free outpatients with depression received antidepressant medication alone (n = 23) or yoga therapy with (n = 26) or without (n = 16) antidepressants. Depression was assessed using the Hamilton Depression Rating Scale. Neuropsychological tests included digit-span forward and backward, Rey Auditory Verbal Learning Test, and Trail Making Tests (TMT-A and B). These tests were administered before and 3 months after the treatment in patients, and once in healthy comparison subjects (n = 19). STATISTICAL ANALYSIS: Baseline differences were analyzed using independent sample t-test, Chi-square, and one-way ANOVA. Paired t-test was used to analyze the change from baseline to follow-up. Pearson's correlation was used to explore the association of change between 2 variables. RESULTS: Patients had impaired performance on most neuropsychological tests. After 3 months, there was significant improvement – patients’ performance was comparable to that of healthy controls on majority of the tests. Significant inverse correlation was observed between increase in BDNF levels and improvement in TMT “A” duration in Yoga-alone group (r = −0.647; P = 0.009). CONCLUSIONS: To conclude that, Yoga therapy, alone or in combination with medications, is associated with improved neuropsychological functions and neuroplastic effects in patients with depression. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5914260/ /pubmed/29736060 http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_154_17 Text en Copyright: © 2018 Indian Journal of Psychiatry http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Halappa, Naveen Gowrapura
Thirthalli, Jagadisha
Varambally, Shivarama
Rao, Mukund
Christopher, Rita
Nanjundaiah, Gangadhar B.
Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title_full Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title_fullStr Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title_full_unstemmed Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title_short Improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
title_sort improvement in neurocognitive functions and serum brain-derived neurotrophic factor levels in patients with depression treated with antidepressants and yoga
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914260/
https://www.ncbi.nlm.nih.gov/pubmed/29736060
http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_154_17
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