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Effects of Genetic Polymorphisms of CYP2B6 on the Pharmacokinetics of Bupropion and Hydroxybupropion in Healthy Chinese Subjects

BACKGROUND: Bupropion (BUP) is an antidepressant and its pharmacological activity is mediated by its major metabolite, hydroxybupropion (HBUP). We investigated the effects of genetic polymorphisms of CYP2B6 on BUP and HBUP to provide certain evidence on the clinical rational administration of BUP. M...

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Detalles Bibliográficos
Autores principales:	Ma, Hui, Zhang, Wenping, Yang, Xiaoying, Zhang, Yuxin, Wei, Shijie, Zhang, Hao, Ma, Yanni, Dang, Hongwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2018
Materias:	Clinical Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914277/ https://www.ncbi.nlm.nih.gov/pubmed/29637923 http://dx.doi.org/10.12659/MSM.909227

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