The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions

Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is o...

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Autores principales: Janciauskiene, Sabina, Wrenger, Sabine, Immenschuh, Stephan, Olejnicka, Beata, Greulich, Timm, Welte, Tobias, Chorostowska-Wynimko, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914301/
https://www.ncbi.nlm.nih.gov/pubmed/29719508
http://dx.doi.org/10.3389/fphar.2018.00341
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author Janciauskiene, Sabina
Wrenger, Sabine
Immenschuh, Stephan
Olejnicka, Beata
Greulich, Timm
Welte, Tobias
Chorostowska-Wynimko, Joanna
author_facet Janciauskiene, Sabina
Wrenger, Sabine
Immenschuh, Stephan
Olejnicka, Beata
Greulich, Timm
Welte, Tobias
Chorostowska-Wynimko, Joanna
author_sort Janciauskiene, Sabina
collection PubMed
description Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils.
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spelling pubmed-59143012018-05-01 The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions Janciauskiene, Sabina Wrenger, Sabine Immenschuh, Stephan Olejnicka, Beata Greulich, Timm Welte, Tobias Chorostowska-Wynimko, Joanna Front Pharmacol Pharmacology Neutrophils are the predominant immune cells in human blood possessing heterogeneity, plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed tissue in response to stimuli are tightly regulated processes. Alpha1-Antitrypsin (AAT), an acute phase protein, is one of the potent regulators of neutrophil activation via both -protease inhibitory and non-inhibitory functions. This review summarizes our current understanding of the effects of AAT on neutrophils, illustrating the interplay between AAT and the key effector functions of neutrophils. Frontiers Media S.A. 2018-04-17 /pmc/articles/PMC5914301/ /pubmed/29719508 http://dx.doi.org/10.3389/fphar.2018.00341 Text en Copyright © 2018 Janciauskiene, Wrenger, Immenschuh, Olejnicka, Greulich, Welte and Chorostowska-Wynimko. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Janciauskiene, Sabina
Wrenger, Sabine
Immenschuh, Stephan
Olejnicka, Beata
Greulich, Timm
Welte, Tobias
Chorostowska-Wynimko, Joanna
The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title_full The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title_fullStr The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title_full_unstemmed The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title_short The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions
title_sort multifaceted effects of alpha1-antitrypsin on neutrophil functions
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914301/
https://www.ncbi.nlm.nih.gov/pubmed/29719508
http://dx.doi.org/10.3389/fphar.2018.00341
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