Cargando…

Oral Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users

Objectives. A once-daily, extended-release hydrocodone bitartrate tablet with abuse-deterrent properties (Hysingla ER [HYD]) is available for the treatment of chronic pain in appropriate patients. This study evaluated the oral abuse potential and pharmacokinetics (PK) of HYD intact, chewed, or mille...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harris, Stephen C., Cipriano, Alessandra, Colucci, Salvatore V., Kapil, Ram P., Geoffroy, Pierre, Hopyan, Talar, Levy-Cooperman, Naama
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	OPIOIDS, SUBSTANCE ABUSE & ADDICTIONS SECTION
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914330/ https://www.ncbi.nlm.nih.gov/pubmed/27651514 http://dx.doi.org/10.1093/pm/pnw208

Ejemplares similares

Intranasal Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users
por: Harris, Stephen C., et al.
Publicado: (2016)

Abuse Potential with Oral Route of Administration of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Darwish, Mona, et al.
Publicado: (2017)

Abuse Potential Study of ALO-02 (Extended-Release Oxycodone Surrounding Sequestered Naltrexone) Compared with Immediate-Release Oxycodone Administered Orally to Nondependent Recreational Opioid Users
por: Setnik, Beatrice, et al.
Publicado: (2017)

Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users
por: Smith, Michael D., et al.
Publicado: (2017)

A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone
por: Webster, Lynn R., et al.
Publicado: (2016)

Consensus Recommendations on Initiating Prescription Therapies for Opioid‐Induced Constipation
por: Argoff, Charles E., et al.
Publicado: (2015)

Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
por: Webster, Lynn, et al.
Publicado: (2016)

ER/LA Opioid Analgesics REMS: Overview of Ongoing Assessments of Its Progress and Its Impact on Health Outcomes
por: Cepeda, M. Soledad, et al.
Publicado: (2017)

Evaluation of the Relative Intranasal Abuse Potential of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Bond, Mary, et al.
Publicado: (2018)

Relative Bioavailability, Intranasal Abuse Potential, and Safety of Benzhydrocodone/Acetaminophen Compared with Hydrocodone Bitartrate/Acetaminophen in Recreational Drug Abusers
por: Guenther, Sven M, et al.
Publicado: (2018)

Pharmacokinetics and Abuse Potential of Benzhydrocodone, a Novel Prodrug of Hydrocodone, After Intranasal Administration in Recreational Drug Users
por: Mickle, Travis C, et al.
Publicado: (2018)

Diversion and Illicit Sale of Extended Release Tapentadol in the United States
por: Dart, Richard C., et al.
Publicado: (2016)

One Month of Oral Morphine Decreases Gray Matter Volume in the Right Amygdala of Individuals with Low Back Pain: Confirmation of Previously Reported Magnetic Resonance Imaging Results
por: Lin, Joanne C., et al.
Publicado: (2016)

A retrospective chart review of opioid represcribing following nonfatal overdose at a Veterans Affairs hospital
por: Boyle, Julia, et al.
Publicado: (2018)

Implementation and results of a symptom-triggered opioid withdrawal protocol at a Veterans Affairs medical center
por: Koch, Jessa, et al.
Publicado: (2018)

Evaluation of buprenorphine/naloxone dose and use of sedating supportive medication on treatment outcomes in veterans with opioid use disorder
por: Kapuganti, Amber, et al.
Publicado: (2018)

Effectiveness and Safety of Once-Daily Extended-Release Hydrocodone in Individuals Previously Receiving Immediate-Release Oxycodone for Chronic Pain
por: Pergolizzi, Joseph, et al.
Publicado: (2018)

Nicotine Gateway Effects on Adolescent Substance Use
por: Ren, Michelle, et al.
Publicado: (2019)

Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) vs Extended-Release Morphine Administered Intranasally in Nondependent Recreational Opioid Users
por: Webster, Lynn R., et al.
Publicado: (2017)

Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users
por: Harris, Stephen C, et al.
Publicado: (2014)

A qualitative investigation of the role of the family in structuring young people’s alcohol use
por: Jacob, Nina, et al.
Publicado: (2016)

Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone
por: Webster, Lynn, et al.
Publicado: (2018)

Oral Human Abuse Potential of Oxycodone DETERx(®) (Xtampza(®) ER)
por: Kopecky, Ernest A., et al.
Publicado: (2016)

Relative Abuse of Crush-Resistant Prescription Opioid Tablets via Alternative Oral Modes of Administration
por: Butler, Stephen F, et al.
Publicado: (2018)

A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation
por: Webster, Lynn R, et al.
Publicado: (2019)

Using machine learning to advance disparities research: Subgroup analyses of access to opioid treatment
por: Kong, Yinfei, et al.
Publicado: (2021)

Are Prescription Opioids Driving the Opioid Crisis? Assumptions vs Facts
por: Rose, Mark Edmund
Publicado: (2018)

Reward-Related Attentional Capture Is Associated With Severity of Addictive and Obsessive–Compulsive Behaviors
por: Albertella, Lucy, et al.
Publicado: (2019)

The Significant Impact of Narcan Reversals on Overdose Mortality in Peoria County, IL
por: AL-Tabbaa, Mohammad Mousbah, et al.
Publicado: (2022)

Importance of Longitudinal Assessments in a Case of Comorbid Polysubstance Use Disorder and Borderline Personality Disorder Misdiagnosed As Bipolar I Disorder
por: Tsyngauz, Esther, et al.
Publicado: (2023)

Discrepancies Between Perceived Benefit of Opioids and Self-Reported Patient Outcomes
por: Goesling, Jenna, et al.
Publicado: (2018)

Laxatives Do Not Improve Symptoms of Opioid-Induced Constipation: Results of a Patient Survey
por: Emmanuel, Anton, et al.
Publicado: (2017)

Rational Urine Drug Monitoring in Patients Receiving Opioids for Chronic Pain: Consensus Recommendations
por: Argoff, Charles E, et al.
Publicado: (2018)

Effect of Preoperative Opioid Use on Adverse Outcomes, Medical Spending, and Persistent Opioid Use Following Elective Total Joint Arthroplasty in the United States: A Large Retrospective Cohort Study of Administrative Claims Data
por: Blevins Peratikos, Meridith, et al.
Publicado: (2020)

Risk of behaviour suggestive of opioid abuse: a protocol for a systematic review of validated assessment tools
por: Galindo, Sheila Raposo, et al.
Publicado: (2018)

A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid
por: Shaparin, Naum, et al.
Publicado: (2017)

Changes in Mortality Involving Extended-Release and Long-Acting Opioids After Implementation of a Risk Evaluation and Mitigation Strategy
por: Black, Joshua C, et al.
Publicado: (2020)

Risk Factors for Serious Prescription Opioid-Induced Respiratory Depression or Overdose: Comparison of Commercially Insured and Veterans Health Affairs Populations
por: Nadpara, Pramit A, et al.
Publicado: (2018)

Trends in investigations of abuse or neglect referred by hospital personnel in Ontario
por: Fallon, Barbara, et al.
Publicado: (2019)

Validation of a Screening Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose in a US Commercial Health Plan Claims Database
por: Zedler, Barbara K, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_5ql91k1onbf7l4echptnqnpji5