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Mediterranean diet and inflammaging within the hormesis paradigm
A coherent set of epidemiological data shows that the Mediterranean diet has beneficial effects capable of preventing a variety of age-related diseases in which low-grade, chronic inflammation/inflammaging plays a major role, but the underpinning mechanism(s) is/are still unclear. It is suggested he...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914347/ https://www.ncbi.nlm.nih.gov/pubmed/28595318 http://dx.doi.org/10.1093/nutrit/nux013 |
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author | Martucci, Morena Ostan, Rita Biondi, Fiammetta Bellavista, Elena Fabbri, Cristina Bertarelli, Claudia Salvioli, Stefano Capri, Miriam Franceschi, Claudio Santoro, Aurelia |
author_facet | Martucci, Morena Ostan, Rita Biondi, Fiammetta Bellavista, Elena Fabbri, Cristina Bertarelli, Claudia Salvioli, Stefano Capri, Miriam Franceschi, Claudio Santoro, Aurelia |
author_sort | Martucci, Morena |
collection | PubMed |
description | A coherent set of epidemiological data shows that the Mediterranean diet has beneficial effects capable of preventing a variety of age-related diseases in which low-grade, chronic inflammation/inflammaging plays a major role, but the underpinning mechanism(s) is/are still unclear. It is suggested here that the Mediterranean diet can be conceptualized as a form of chronic hormetic stress, similar to what has been proposed regarding calorie restriction, the most thoroughly studied nutritional intervention. Data on the presence in key Mediterranean foods of a variety of compounds capable of exerting hormetic effects are summarized, and the mechanistic role of the nuclear factor erythroid 2 pathway is highlighted. Within this conceptual framework, particular attention has been devoted to the neurohormetic and neuroprotective properties of the Mediterranean diet, as well as to its ability to maintain an optimal balance between pro- and anti-inflammaging. Finally, the European Commission–funded project NU-AGE is discussed because it addresses a number of variables not commonly taken into consideration, such as age, sex, and ethnicity/genetics, that can modulate the hormetic effect of the Mediterranean diet. |
format | Online Article Text |
id | pubmed-5914347 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-59143472018-05-04 Mediterranean diet and inflammaging within the hormesis paradigm Martucci, Morena Ostan, Rita Biondi, Fiammetta Bellavista, Elena Fabbri, Cristina Bertarelli, Claudia Salvioli, Stefano Capri, Miriam Franceschi, Claudio Santoro, Aurelia Nutr Rev Special Articles A coherent set of epidemiological data shows that the Mediterranean diet has beneficial effects capable of preventing a variety of age-related diseases in which low-grade, chronic inflammation/inflammaging plays a major role, but the underpinning mechanism(s) is/are still unclear. It is suggested here that the Mediterranean diet can be conceptualized as a form of chronic hormetic stress, similar to what has been proposed regarding calorie restriction, the most thoroughly studied nutritional intervention. Data on the presence in key Mediterranean foods of a variety of compounds capable of exerting hormetic effects are summarized, and the mechanistic role of the nuclear factor erythroid 2 pathway is highlighted. Within this conceptual framework, particular attention has been devoted to the neurohormetic and neuroprotective properties of the Mediterranean diet, as well as to its ability to maintain an optimal balance between pro- and anti-inflammaging. Finally, the European Commission–funded project NU-AGE is discussed because it addresses a number of variables not commonly taken into consideration, such as age, sex, and ethnicity/genetics, that can modulate the hormetic effect of the Mediterranean diet. Oxford University Press 2017-06 2017-06-08 /pmc/articles/PMC5914347/ /pubmed/28595318 http://dx.doi.org/10.1093/nutrit/nux013 Text en © The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Special Articles Martucci, Morena Ostan, Rita Biondi, Fiammetta Bellavista, Elena Fabbri, Cristina Bertarelli, Claudia Salvioli, Stefano Capri, Miriam Franceschi, Claudio Santoro, Aurelia Mediterranean diet and inflammaging within the hormesis paradigm |
title | Mediterranean diet and inflammaging within the hormesis paradigm |
title_full | Mediterranean diet and inflammaging within the hormesis paradigm |
title_fullStr | Mediterranean diet and inflammaging within the hormesis paradigm |
title_full_unstemmed | Mediterranean diet and inflammaging within the hormesis paradigm |
title_short | Mediterranean diet and inflammaging within the hormesis paradigm |
title_sort | mediterranean diet and inflammaging within the hormesis paradigm |
topic | Special Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914347/ https://www.ncbi.nlm.nih.gov/pubmed/28595318 http://dx.doi.org/10.1093/nutrit/nux013 |
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