Cargando…

A Phase 2b, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients with Chronic Noncancer Pain

OBJECTIVE: This study evaluated the efficacy and safety of oral naldemedine 0.1 mg, 0.2 mg, or 0.4 mg once daily in patients who had opioid-induced constipation (OIC) and maintained a stable laxative regimen. METHODS: This four-week, phase 2b, randomized, double-blind placebo-controlled trial (clini...

Descripción completa

Detalles Bibliográficos
Autores principales:	Webster, Lynn R, Yamada, Tadaaki, Arjona Ferreira, Juan Camilo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	OPIOIDS & SUBSTANCE USE DISORDERS SECTION
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914456/ https://www.ncbi.nlm.nih.gov/pubmed/28371937 http://dx.doi.org/10.1093/pm/pnw325

Ejemplares similares

Long-Term Safety and Efficacy of Subcutaneous Methylnaltrexone in Patients with Opioid-Induced Constipation and Chronic Noncancer Pain: A Phase 3, Open-Label Trial
por: Webster, Lynn R., et al.
Publicado: (2017)

A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, Intranasal Human Abuse Potential Study of Oxycodone ARIR, a Novel, Immediate-Release, Abuse-Deterrent Formulation
por: Webster, Lynn R, et al.
Publicado: (2019)

Laxatives Do Not Improve Symptoms of Opioid-Induced Constipation: Results of a Patient Survey
por: Emmanuel, Anton, et al.
Publicado: (2017)

Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone
por: Webster, Lynn, et al.
Publicado: (2018)

Evaluation of the Relative Intranasal Abuse Potential of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Bond, Mary, et al.
Publicado: (2018)

Rational Urine Drug Monitoring in Patients Receiving Opioids for Chronic Pain: Consensus Recommendations
por: Argoff, Charles E, et al.
Publicado: (2018)

Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) vs Extended-Release Morphine Administered Intranasally in Nondependent Recreational Opioid Users
por: Webster, Lynn R., et al.
Publicado: (2017)

Are Prescription Opioids Driving the Opioid Crisis? Assumptions vs Facts
por: Rose, Mark Edmund
Publicado: (2018)

Discrepancies Between Perceived Benefit of Opioids and Self-Reported Patient Outcomes
por: Goesling, Jenna, et al.
Publicado: (2018)

Effect of Preoperative Opioid Use on Adverse Outcomes, Medical Spending, and Persistent Opioid Use Following Elective Total Joint Arthroplasty in the United States: A Large Retrospective Cohort Study of Administrative Claims Data
por: Blevins Peratikos, Meridith, et al.
Publicado: (2020)

Relative Abuse of Crush-Resistant Prescription Opioid Tablets via Alternative Oral Modes of Administration
por: Butler, Stephen F, et al.
Publicado: (2018)

A Novel Chronic Opioid Monitoring Tool to Assess Prescription Drug Steady State Levels in Oral Fluid
por: Shaparin, Naum, et al.
Publicado: (2017)

Changes in Mortality Involving Extended-Release and Long-Acting Opioids After Implementation of a Risk Evaluation and Mitigation Strategy
por: Black, Joshua C, et al.
Publicado: (2020)

Understanding Buprenorphine for Use in Chronic Pain: Expert Opinion
por: Webster, Lynn, et al.
Publicado: (2020)

Risk Factors for Serious Prescription Opioid-Induced Respiratory Depression or Overdose: Comparison of Commercially Insured and Veterans Health Affairs Populations
por: Nadpara, Pramit A, et al.
Publicado: (2018)

Pharmacokinetics and Abuse Potential of Benzhydrocodone, a Novel Prodrug of Hydrocodone, After Intranasal Administration in Recreational Drug Users
por: Mickle, Travis C, et al.
Publicado: (2018)

Validation of a Screening Risk Index for Serious Prescription Opioid-Induced Respiratory Depression or Overdose in a US Commercial Health Plan Claims Database
por: Zedler, Barbara K, et al.
Publicado: (2018)

Measuring Opioid Withdrawal in a Phase 3 Study of a New Analgesic, NKTR-181 (Oxycodegol), in Patients with Moderate to Severe Chronic Low Back Pain
por: Henningfield, Jack E, et al.
Publicado: (2020)

Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: a randomized, double-blind, placebo-controlled phase 3 study
por: Webster, Lynn R., et al.
Publicado: (2018)

Consensus Recommendations on Initiating Prescription Therapies for Opioid‐Induced Constipation
por: Argoff, Charles E., et al.
Publicado: (2015)

Effectiveness and Safety of Once-Daily Extended-Release Hydrocodone in Individuals Previously Receiving Immediate-Release Oxycodone for Chronic Pain
por: Pergolizzi, Joseph, et al.
Publicado: (2018)

Relative Bioavailability, Intranasal Abuse Potential, and Safety of Benzhydrocodone/Acetaminophen Compared with Hydrocodone Bitartrate/Acetaminophen in Recreational Drug Abusers
por: Guenther, Sven M, et al.
Publicado: (2018)

Onset of action of naldemedine in the treatment of opioid-induced constipation in patients with chronic noncancer pain: results from 2 randomized, placebo-controlled, phase 3 trials
por: Wild, James, et al.
Publicado: (2019)

Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
por: Chaves, Carolina, et al.
Publicado: (2020)

A Randomized, Double-Blind, Double-Dummy Study to Evaluate the Intranasal Human Abuse Potential and Pharmacokinetics of a Novel Extended-Release Abuse-Deterrent Formulation of Oxycodone
por: Webster, Lynn R., et al.
Publicado: (2016)

A Randomized, Placebo-Controlled Trial of Lubiprostone for Opioid-Induced Constipation in Chronic Noncancer Pain
por: Jamal, M Mazen, et al.
Publicado: (2015)

Evaluation of the Tolerability of Switching Patients on Chronic Full μ-Opioid Agonist Therapy to Buccal Buprenorphine
por: Webster, Lynn, et al.
Publicado: (2016)

Update on the role of naldemedine in opioid-induced constipation in patients with chronic noncancer pain
por: BouSaba, Joelle, et al.
Publicado: (2022)

Abuse Potential with Oral Route of Administration of a Hydrocodone Extended-Release Tablet Formulated with Abuse-Deterrence Technology in Nondependent, Recreational Opioid Users
por: Darwish, Mona, et al.
Publicado: (2017)

Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users
por: Smith, Michael D., et al.
Publicado: (2017)

Cultural adaptation of two school-based smoking prevention programs in Bogotá, Colombia
por: Sánchez-Franco, Sharon, et al.
Publicado: (2021)

Correlates of patterns of cannabis use, abuse and dependence: evidence from two national surveys in Ireland
por: Millar, Seán R, et al.
Publicado: (2021)

Friendship Conflict, Drinking to Cope, and Alcohol-Related Problems: A Longitudinal Actor-Partner Interdependence Model
por: Mackinnon, Sean P., et al.
Publicado: (2022)

The relationship between substance use disorder and gambling disorder: A nationwide longitudinal health registry study
por: Leino, Tony, et al.
Publicado: (2021)

Does the suddenness matter? Antidepressant use before and after a spouse dies suddenly or expectedly of stroke
por: Einiö, Elina, et al.
Publicado: (2021)

Which illicit drugs are injected in Oslo? A study based on analysis of drug residues in used injection equipment and self-reported information
por: Gjerde, Hallvard, et al.
Publicado: (2021)

Increases in drug overdose deaths in Norway and the United States during the COVID-19 pandemic
por: Friedman, Joseph, et al.
Publicado: (2022)

Cannabis use disorder in relation to socioeconomic factors and psychiatric comorbidity: A cluster analysis of three million individuals born in 1970–2000
por: Rabiee, Rynaz, et al.
Publicado: (2022)

Socio-demographic differences in polypharmacy and potentially inappropriate drug use among older people with different care needs and in care settings in Stockholm, Sweden
por: Doheny, Megan, et al.
Publicado: (2021)

Trends in public attitudes to permitting cannabis for recreational use: analysis of Irish survey data since 2002
por: Mongan, Deirdre, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lfe7tb14no462iussk151i4ebh