Cargando…

Design, synthesis, and structure–activity relationships of 2-benzylidene-1-indanone derivatives as anti-inflammatory agents for treatment of acute lung injury

PURPOSE: The purpose of this study was to design and synthesize novel 2-benzylidene-1-indanone derivatives for treatment of acute lung injury. METHODS: A series of 39 novel 2-benzylidene-indanone structural derivatives were synthesized and evaluated for anti-inflammatory activity in lipopolysacchari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Siyang, Zhang, Wenxin, Chen, Hongjin, Fang, Bo, Qiu, Yinda, Chen, Xianxin, Chen, Lingfeng, Shu, Sheng, Zhang, Yali, Zhao, Yunjie, Liu, Zhiguo, Liang, Guang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914570/ https://www.ncbi.nlm.nih.gov/pubmed/29719375 http://dx.doi.org/10.2147/DDDT.S160314

Ejemplares similares

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives
por: Jung, Hee Jin, et al.
Publicado: (2019)

Design, Synthesis, and Bioactivity of Chalcone Derivatives Containing Indanone
por: Sun, Nan, et al.
Publicado: (2023)

Non-Conventional Methodologies in the Synthesis of 1-Indanones
por: Oliverio, Manuela, et al.
Publicado: (2014)

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2022)

Synthesis of 1-indanones with a broad range of biological activity
por: Turek, Marika, et al.
Publicado: (2017)

Hydrogen radical-shuttle (HRS)-enabled photoredox synthesis of indanones via decarboxylative annulation
por: Yang, Bo, et al.
Publicado: (2021)

Synthesis of spirocyclic Δ(4)-isoxazolines via [3 + 2] cycloaddition of indanone-derived ketonitrones with alkynes
por: Liu, Yilin, et al.
Publicado: (2021)

Annulations involving 1-indanones to access fused- and spiro frameworks
por: Das, Suven, et al.
Publicado: (2022)

Dual A(1) and A(2A) adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, suppresses intestinal postprandial glucose and attenuates hyperglycaemia in fructose-streptozotocin diabetic rats
por: Sanni, Olakunle, et al.
Publicado: (2023)

Biomimetic synthesis of the natural product salviadione and its hybrids: discovery of tissue-specific anti-inflammatory agents for acute lung injury
por: Ding, Chunyong, et al.
Publicado: (2019)

Copper-Catalyzed Annulation–Cyanotrifluoromethylation of 1,6-Enynes Toward 1-Indanones via a Radical Process
por: Zhang, Tian-Shu, et al.
Publicado: (2020)

Computational and Preclinical Analysis of 2-(4-Methyl)benzylidene-4,7-dimethyl Indan-1-one (IPX-18): A Novel Arylidene Indanone Small Molecule with Anti-Inflammatory Activity via NF-κB and Nrf2 Signaling
por: Gahtani, Reem M., et al.
Publicado: (2023)

Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis
por: Liang, Yumeng, et al.
Publicado: (2019)

A novel resveratrol analog PA19 attenuates obesity-induced cardiac and renal injury by inhibiting inflammation and inflammatory cell infiltration
por: Zhang, Wenxin, et al.
Publicado: (2019)

Anticancer effect of Indanone-based thiazolyl hydrazone derivative on p53 mutant colorectal cancer cell lines: An in vitro and in vivo study
por: Narayanan, Silpa, et al.
Publicado: (2022)

Efficient kinetic resolution in the asymmetric transfer hydrogenation of 3-aryl-indanones: applications to a short synthesis of (+)-indatraline and a formal synthesis of (R)-tolterodine
por: Park, Songsoon, et al.
Publicado: (2021)

1-[4-(β-d-Allopyranosyloxy)benzylidene]semicarbazide hemihydrate
por: Chen, Hua-Feng, et al.
Publicado: (2010)

A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo
por: Ge, Xiangting, et al.
Publicado: (2016)

Asymmetric Electrophilic Difluoromethylthiolation of Indanone-Based β-Keto Esters Using Difluoromethanesulfonyl Hypervalent Iodonium Ylides
por: Gondo, Satoshi, et al.
Publicado: (2019)

Catalytic Asymmetric Fluorination of Alkyl 1-indanone-2-carboxylates Ruled by Pybox-Eu(III) Combination
por: Granados, Albert, et al.
Publicado: (2019)

Ring Expansion of 1-Indanones to 2-Halo-1-naphthols as an Entry Point to Gilvocarcin Natural Products
por: Zamarija, Ivica, et al.
Publicado: (2021)

Discovery and evaluation of asymmetrical monocarbonyl analogs of curcumin as anti-inflammatory agents
por: Zhang, Yali, et al.
Publicado: (2014)

Anticorrosion Agents for Carbon Steel in Acidic Environments: Synthesis and Quantum Chemical Analysis of New Schiff Base Compounds with Benzylidene
por: Thabet, Hamdy Khamees, et al.
Publicado: (2023)

Myeloid Differentiation Protein 2 Mediates Angiotensin II-Induced Liver Inflammation and Fibrosis in Mice
por: Zhang, Yi, et al.
Publicado: (2019)

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

Synthesis and Evaluation of New β-Carboline-3-(4-benzylidene)-4H-oxazol-5-one Derivatives as Antitumor Agents
por: Savariz, Franciele Cristina, et al.
Publicado: (2012)

Novel benzylidene benzofuranone analogues as potential anticancer agents: design, synthesis and in vitro evaluation based on CDK2 inhibition assays
por: Pai, Aravinda, et al.
Publicado: (2022)

Diastereoselective synthesis of novel spiro indanone fused pyrano[3,2-c]chromene derivatives following hetero-Diels–Alder reaction and in vitro anticancer studies
por: Panda, Pravati, et al.
Publicado: (2018)

Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins
por: Zhai, Jiang-Song, et al.
Publicado: (2022)

A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation
por: Liu, Chan, et al.
Publicado: (2022)

Design, Synthesis, In Silico and POM Studies for the Identification of the Pharmacophore Sites of Benzylidene Derivatives
por: Hosen, Mohammad I., et al.
Publicado: (2023)

Conformational analysis, molecular structure, spectroscopic, NBO, reactivity descriptors, wavefunction and molecular docking investigations of 5,6-dimethoxy-1-indanone: A potential anti Alzheimer's agent
por: Sebastian, S., et al.
Publicado: (2022)

1-Benzylidene-4-ethylthiosemicarbazide
por: Li, Yu-Feng, et al.
Publicado: (2010)

The synthesis of N,N′-disulfanediyl-bis(N′-((E)-benzylidene)acetohydrazide) from (E)-N′-benzylideneacetohydrazide and S(8)
por: Liu, Hong-Yan, et al.
Publicado: (2020)

Synthesis and biological evaluation of novel indole-2-one and 7-aza-2-oxindole derivatives as anti-inflammatory agents
por: Chen, Gaozhi, et al.
Publicado: (2014)

Synthesis and In vitro cytotoxic activity evaluation of (E)-16-(substituted benzylidene) derivatives of dehydroepiandrosterone
por: Vosooghi, Mohsen, et al.
Publicado: (2013)

Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
por: Kumar, Davinder, et al.
Publicado: (2010)

The Synthesis and Herbicidal Activity of 1-Alkyl-3-(α-hydroxy-substituted benzylidene)pyrrolidine-2,4-diones
por: Zhu, You-Quan, et al.
Publicado: (2005)

Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats
por: Shan, Xiaoou, et al.
Publicado: (2017)

5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies
por: Haroun, Michelyne, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_iqdr2pmmhnnamiipe7aspqmla7