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Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran
BACKGROUND AND PURPOSE: Breastfeeding plays an important role in the growth and development of infants. However, breast milk may be contaminated with various mycotoxins. Ochratoxin A is one of the most important mycotoxins with nephrotoxic, carcinogenic, teratogenic, genotoxic, and immunotoxic prope...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Society of Medical Mycology
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914919/ https://www.ncbi.nlm.nih.gov/pubmed/29707666 http://dx.doi.org/10.29252/cmm.3.3.1 |
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author | Kamali, Ali Mehni, Sareh Kamali, Mohadeseh Taheri Sarvtin, Mehdi |
author_facet | Kamali, Ali Mehni, Sareh Kamali, Mohadeseh Taheri Sarvtin, Mehdi |
author_sort | Kamali, Ali |
collection | PubMed |
description | BACKGROUND AND PURPOSE: Breastfeeding plays an important role in the growth and development of infants. However, breast milk may be contaminated with various mycotoxins. Ochratoxin A is one of the most important mycotoxins with nephrotoxic, carcinogenic, teratogenic, genotoxic, and immunotoxic properties. Thus, we carried out this study to determine the concentration of ochratoxin A in human breast milk in Jiroft, Kerman Province, south of Iran. MATERIALS AND METHODS: Eighty-four human breast milk samples were collected from mothers visiting the number one clinic in Jiroft city. Enzyme-linked immunosorbent assay (ELISA) was used to detect ochratoxin A in the samples. RESULTS: Ochratoxin A was found in all the tested samples at a concentration ranging from 0.11 to 7.34 ng/ml. The mean concentration of ochratoxin A in the samples was 1.99±1.34 ng/ml. Fourteen samples contained ochratoxin A at concentrations exceeding the quantitation limit (3 ng/ml). CONCLUSION: The results of this study showed that infants are exposed to ochratoxin A in our region. In cases exceeding the quantitation limit, the infant's body cannot detoxify the toxin. Therefore, the infant can be affected by various illnesses such as nephropathy, immune system deficiency, and different types of cancer. |
format | Online Article Text |
id | pubmed-5914919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Iranian Society of Medical Mycology |
record_format | MEDLINE/PubMed |
spelling | pubmed-59149192018-04-27 Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran Kamali, Ali Mehni, Sareh Kamali, Mohadeseh Taheri Sarvtin, Mehdi Curr Med Mycol Original Article BACKGROUND AND PURPOSE: Breastfeeding plays an important role in the growth and development of infants. However, breast milk may be contaminated with various mycotoxins. Ochratoxin A is one of the most important mycotoxins with nephrotoxic, carcinogenic, teratogenic, genotoxic, and immunotoxic properties. Thus, we carried out this study to determine the concentration of ochratoxin A in human breast milk in Jiroft, Kerman Province, south of Iran. MATERIALS AND METHODS: Eighty-four human breast milk samples were collected from mothers visiting the number one clinic in Jiroft city. Enzyme-linked immunosorbent assay (ELISA) was used to detect ochratoxin A in the samples. RESULTS: Ochratoxin A was found in all the tested samples at a concentration ranging from 0.11 to 7.34 ng/ml. The mean concentration of ochratoxin A in the samples was 1.99±1.34 ng/ml. Fourteen samples contained ochratoxin A at concentrations exceeding the quantitation limit (3 ng/ml). CONCLUSION: The results of this study showed that infants are exposed to ochratoxin A in our region. In cases exceeding the quantitation limit, the infant's body cannot detoxify the toxin. Therefore, the infant can be affected by various illnesses such as nephropathy, immune system deficiency, and different types of cancer. Iranian Society of Medical Mycology 2017-09 /pmc/articles/PMC5914919/ /pubmed/29707666 http://dx.doi.org/10.29252/cmm.3.3.1 Text en © 2017, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kamali, Ali Mehni, Sareh Kamali, Mohadeseh Taheri Sarvtin, Mehdi Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title | Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title_full | Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title_fullStr | Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title_full_unstemmed | Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title_short | Detection of ochratoxin A in human breast milk in Jiroft city, south of Iran |
title_sort | detection of ochratoxin a in human breast milk in jiroft city, south of iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914919/ https://www.ncbi.nlm.nih.gov/pubmed/29707666 http://dx.doi.org/10.29252/cmm.3.3.1 |
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