Cargando…

Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells

HuR plays an important role in tumor cell survival mainly through posttranscriptional upregulation of prominent anti-apoptotic genes. In addition, HuR can inhibit the translation of pro-apoptotic factors as we could previously report for caspase-2. Here, we investigated the mechanisms of caspase-2 s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Badawi, Amel, Biyanee, Abhiruchi, Nasrullah, Usman, Winslow, Sofia, Schmid, Tobias, Pfeilschifter, Josef, Eberhardt, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915078/ https://www.ncbi.nlm.nih.gov/pubmed/29719611 http://dx.doi.org/10.18632/oncotarget.24840

Ejemplares similares

Cytoskeleton-Dependent Transport as a Potential Target for Interfering with Post-transcriptional HuR mRNA Regulons
por: Eberhardt, Wolfgang, et al.
Publicado: (2016)

Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis
por: Nasrullah, Usman, et al.
Publicado: (2019)

Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
por: Eberhardt, Wolfgang, et al.
Publicado: (2019)

Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L
por: Winkler, C, et al.
Publicado: (2014)

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes
por: Doller, Anke, et al.
Publicado: (2013)

Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence
por: Yi, Jie, et al.
Publicado: (2010)

MCD Diet Modulates HuR and Oxidative Stress-Related HuR Targets in Rats
por: Ferrigno, Andrea, et al.
Publicado: (2023)

Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2019)

Translation, Pdcd4 and eIF4A
por: Biyanee, Abhiruchi, et al.
Publicado: (2015)

Multifaceted Roles of TRIM Proteins in Colorectal Carcinoma
por: Eberhardt, Wolfgang, et al.
Publicado: (2020)

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs
por: Yoon, Je-Hyun, et al.
Publicado: (2014)

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro
por: Kaur, Kawaljit, et al.
Publicado: (2017)

Correction: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation
por: Yang, Feng, et al.
Publicado: (2023)

7SL RNA represses p53 translation by competing with HuR
por: Abdelmohsen, Kotb, et al.
Publicado: (2014)

Hu Antigen R (HuR) Protein Structure, Function and Regulation in Hepatobiliary Tumors
por: Lachiondo-Ortega, Sofia, et al.
Publicado: (2022)

The E3 Ligase TRIM25 Impairs Apoptotic Cell Death in Colon Carcinoma Cells via Destabilization of Caspase-7 mRNA: A Possible Role of hnRNPH1
por: Nasrullah, Usman, et al.
Publicado: (2023)

Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
por: Mazroui, Rachid, et al.
Publicado: (2008)

The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
por: Meng, Zheng, et al.
Publicado: (2005)

HuB and HuD repress telomerase activity by dissociating HuR from TERC
por: Cheng, Xiaolei, et al.
Publicado: (2021)

HuR controls mitochondrial morphology through the regulation of Bcl(xL) translation
por: Durie, Danielle, et al.
Publicado: (2013)

Regulation of HuR by DNA Damage Response Kinases
por: Kim, Hyeon Ho, et al.
Publicado: (2010)

Regulation of HuR structure and function by dihydrotanshinone-I
por: Lal, Preet, et al.
Publicado: (2017)

The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions
por: Eichler, Madeleine, et al.
Publicado: (2022)

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA
por: Dormoy-Raclet, Virginie, et al.
Publicado: (2013)

Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance
por: Zhou, Yi, et al.
Publicado: (2016)

Regulation of AT1R expression through HuR by insulin
por: Paukku, Kirsi, et al.
Publicado: (2012)

MiR-200c and HuR in ovarian cancer
por: Prislei, Silvia, et al.
Publicado: (2013)

HuR regulates telomerase activity through TERC methylation
por: Tang, Hao, et al.
Publicado: (2018)

Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR
por: Chen, Gang, et al.
Publicado: (2019)

The RNA-Binding Protein HuR in Digestive System Tumors
por: Song, Xiaoqing, et al.
Publicado: (2020)

HuR modulation counteracts lipopolysaccharide response in murine macrophages
por: Bonomo, Isabelle, et al.
Publicado: (2023)

HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth
por: Liebig, Janika K., et al.
Publicado: (2020)

Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function
por: Yu, Ting-Xi, et al.
Publicado: (2011)

RNA-binding proteins La and HuR cooperatively modulate translation repression of PDCD4 mRNA
por: Kumar, Ravi, et al.
Publicado: (2020)

Different modes of interaction by TIAR and HuR with target RNA and DNA
por: Kim, Henry S., et al.
Publicado: (2011)

The Role of HuR in the Post-Transcriptional Regulation of Interleukin-3 in T Cells
por: González-Feliciano, José A., et al.
Publicado: (2014)

Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas
por: Levidou, Georgia, et al.
Publicado: (2018)

The RNA-binding protein HuR is a negative regulator in adipogenesis
por: Siang, Diana Teh Chee, et al.
Publicado: (2020)

HuR Protein in Hepatocellular Carcinoma: Implications in Development, Prognosis and Treatment
por: Papatheofani, Vasiliki, et al.
Publicado: (2021)

Eltrombopag Inhibits Metastasis in Breast Carcinoma by Targeting HuR Protein
por: Chen, Yao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gkul39joebrq6j012f18rlnur4