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Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals
The rapid evolution of reproductive proteins might be driven by positive Darwinian selection. The bone morphogenetic protein family is the largest within the transforming growth factor (TGF) superfamily. A little have been known about the molecular evolution of bone morphogenetic proteins exhibiting...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915083/ https://www.ncbi.nlm.nih.gov/pubmed/29719616 http://dx.doi.org/10.18632/oncotarget.24240 |
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author | Ahmad, Hafiz Ishfaq Ahmad, Muhammad Jamil Adeel, Muhammad Muzammal Asif, Akhtar Rasool Du, Xiaoyong |
author_facet | Ahmad, Hafiz Ishfaq Ahmad, Muhammad Jamil Adeel, Muhammad Muzammal Asif, Akhtar Rasool Du, Xiaoyong |
author_sort | Ahmad, Hafiz Ishfaq |
collection | PubMed |
description | The rapid evolution of reproductive proteins might be driven by positive Darwinian selection. The bone morphogenetic protein family is the largest within the transforming growth factor (TGF) superfamily. A little have been known about the molecular evolution of bone morphogenetic proteins exhibiting potential role in mammalian reproduction. In this study we investigated mammalian bone morphogenetic proteins using maximum likelihood approaches of codon substitutions to identify positive Darwinian selection in various species. The proportion of positively selected sites was tested by different likelihood models for individual codon, and M8 were found to be the best model. The percentage of positively elected sites under M8 are 2.20% with ω = 1.089 for BMP2, 1.6% with ω = 1.61 for BMP 4 0.53% for BMP15 with ω = 1.56 and 0.78% for GDF9 with ω = 1.93. The percentage of estimated selection sites under M8 is strong statistical confirmation that divergence of bone morphogenetic proteins is driven by Darwinian selection. For the proteins, model M8 was found significant for all proteins with ω > 1. To further test positive selection on particular amino acids, the evolutionary conservation of amino acid were measured based on phylogenetic linkage among sequences. For exploring the impact of these somatic substitution mutations in the selection region on human cancer, we identified one pathogenic mutation in human BMP4 and one in BMP15, possibly causing prostate cancer and six neutral mutations in BMPs. The comprehensive map of selection results allows the researchers to perform systematic approaches to detect the evolutionary footprints of selection on specific gene in specific species. |
format | Online Article Text |
id | pubmed-5915083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59150832018-05-01 Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals Ahmad, Hafiz Ishfaq Ahmad, Muhammad Jamil Adeel, Muhammad Muzammal Asif, Akhtar Rasool Du, Xiaoyong Oncotarget Research Paper The rapid evolution of reproductive proteins might be driven by positive Darwinian selection. The bone morphogenetic protein family is the largest within the transforming growth factor (TGF) superfamily. A little have been known about the molecular evolution of bone morphogenetic proteins exhibiting potential role in mammalian reproduction. In this study we investigated mammalian bone morphogenetic proteins using maximum likelihood approaches of codon substitutions to identify positive Darwinian selection in various species. The proportion of positively selected sites was tested by different likelihood models for individual codon, and M8 were found to be the best model. The percentage of positively elected sites under M8 are 2.20% with ω = 1.089 for BMP2, 1.6% with ω = 1.61 for BMP 4 0.53% for BMP15 with ω = 1.56 and 0.78% for GDF9 with ω = 1.93. The percentage of estimated selection sites under M8 is strong statistical confirmation that divergence of bone morphogenetic proteins is driven by Darwinian selection. For the proteins, model M8 was found significant for all proteins with ω > 1. To further test positive selection on particular amino acids, the evolutionary conservation of amino acid were measured based on phylogenetic linkage among sequences. For exploring the impact of these somatic substitution mutations in the selection region on human cancer, we identified one pathogenic mutation in human BMP4 and one in BMP15, possibly causing prostate cancer and six neutral mutations in BMPs. The comprehensive map of selection results allows the researchers to perform systematic approaches to detect the evolutionary footprints of selection on specific gene in specific species. Impact Journals LLC 2018-01-13 /pmc/articles/PMC5915083/ /pubmed/29719616 http://dx.doi.org/10.18632/oncotarget.24240 Text en Copyright: © 2018 Ahmad et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Ahmad, Hafiz Ishfaq Ahmad, Muhammad Jamil Adeel, Muhammad Muzammal Asif, Akhtar Rasool Du, Xiaoyong Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title | Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title_full | Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title_fullStr | Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title_full_unstemmed | Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title_short | Positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
title_sort | positive selection drives the evolution of endocrine regulatory bone morphogenetic protein system in mammals |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915083/ https://www.ncbi.nlm.nih.gov/pubmed/29719616 http://dx.doi.org/10.18632/oncotarget.24240 |
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