Inhibition of aldose-reductase-2 by a benzofuroxane derivative bf-5m increases the expression of kcne1, kcnq1 in high glucose cultured H9c2 cardiac cells and sudden cardiac death

Long QT syndrome (LQTS) is characterized by prolonged QT interval, leading to sudden cardiac death. Hyperglycemia is an important risk factor for LQTS, inhibiting the cardiac rapid component delayed rectifier K+ current (Iks), responsible for QT interval. We previously showed that the new ALR2 inhib...

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Detalles Bibliográficos
Autores principales: Trotta, Maria Consiglia, Salerno, Monica, Brigida, Anna Lisa, Monda, Vincenzo, Messina, Antonietta, Fiore, Carmela, Avola, Roberto, Bernardini, Renato, Sessa, Francesco, Marsala, Gabriella, Zanghì, Guido N., Messina, Giovanni, D’Amico, Michele, Di Filippo, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915114/
https://www.ncbi.nlm.nih.gov/pubmed/29707106
http://dx.doi.org/10.18632/oncotarget.23270

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