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Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma?
Recent studies involving melanoma cell lines suggest that enhanced expression of epigenetic regulator RNF2 supports proliferation and promotes metastasis. However, it is not clear to what extent those data apply to disease progression and prognosis for melanoma patients. Therefore the aim of the pre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915146/ https://www.ncbi.nlm.nih.gov/pubmed/29707138 http://dx.doi.org/10.18632/oncotarget.24825 |
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author | Kuźbicki, Łukasz Lange, Dariusz Stanek-Widera, Agata Glińska, Agnieszka Chwirot, Barbara W. |
author_facet | Kuźbicki, Łukasz Lange, Dariusz Stanek-Widera, Agata Glińska, Agnieszka Chwirot, Barbara W. |
author_sort | Kuźbicki, Łukasz |
collection | PubMed |
description | Recent studies involving melanoma cell lines suggest that enhanced expression of epigenetic regulator RNF2 supports proliferation and promotes metastasis. However, it is not clear to what extent those data apply to disease progression and prognosis for melanoma patients. Therefore the aim of the present study was to assess the prognostic power of RNF2 intratumoral expression by melanoma cells. RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases. The lowest percentage of RNF2-positive melanocytes found in nevi was comparable to expression levels in normal skin. The RNF2 expression found in melanomas was significantly higher and it was even more enhanced in metastases. The increased occurrence of RNF2 expressing cells was positively correlated with longer patients’ overall survival. Moreover, a negative correlation was found between intratumoral RNF2 expression and number of generated metastatic lesions. Our data indicate that development of melanoma is associated with significant changes in RNF2 intratumoral expression and imply that at least for some patients the enhancement of the expression levels of RNF2 in both primary and metastatic lesions may be considered a favorable prognostic factor in melanoma. |
format | Online Article Text |
id | pubmed-5915146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-59151462018-04-27 Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? Kuźbicki, Łukasz Lange, Dariusz Stanek-Widera, Agata Glińska, Agnieszka Chwirot, Barbara W. Oncotarget Research Paper Recent studies involving melanoma cell lines suggest that enhanced expression of epigenetic regulator RNF2 supports proliferation and promotes metastasis. However, it is not clear to what extent those data apply to disease progression and prognosis for melanoma patients. Therefore the aim of the present study was to assess the prognostic power of RNF2 intratumoral expression by melanoma cells. RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases. The lowest percentage of RNF2-positive melanocytes found in nevi was comparable to expression levels in normal skin. The RNF2 expression found in melanomas was significantly higher and it was even more enhanced in metastases. The increased occurrence of RNF2 expressing cells was positively correlated with longer patients’ overall survival. Moreover, a negative correlation was found between intratumoral RNF2 expression and number of generated metastatic lesions. Our data indicate that development of melanoma is associated with significant changes in RNF2 intratumoral expression and imply that at least for some patients the enhancement of the expression levels of RNF2 in both primary and metastatic lesions may be considered a favorable prognostic factor in melanoma. Impact Journals LLC 2018-04-03 /pmc/articles/PMC5915146/ /pubmed/29707138 http://dx.doi.org/10.18632/oncotarget.24825 Text en Copyright: © 2018 Kuźbicki et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kuźbicki, Łukasz Lange, Dariusz Stanek-Widera, Agata Glińska, Agnieszka Chwirot, Barbara W. Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title | Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title_full | Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title_fullStr | Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title_full_unstemmed | Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title_short | Enhanced intratumoral expression of RNF2 is a favorable prognostic factor for patients with cutaneous melanoma? |
title_sort | enhanced intratumoral expression of rnf2 is a favorable prognostic factor for patients with cutaneous melanoma? |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915146/ https://www.ncbi.nlm.nih.gov/pubmed/29707138 http://dx.doi.org/10.18632/oncotarget.24825 |
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