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Full disclosure: Genome assembly is still hard

Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies...

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Detalles Bibliográficos
Autor principal: Richards, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915270/
https://www.ncbi.nlm.nih.gov/pubmed/29689052
http://dx.doi.org/10.1371/journal.pbio.2005894
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author Richards, Stephen
author_facet Richards, Stephen
author_sort Richards, Stephen
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description Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies—especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics.
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spelling pubmed-59152702018-05-11 Full disclosure: Genome assembly is still hard Richards, Stephen PLoS Biol Primer Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies—especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics. Public Library of Science 2018-04-24 /pmc/articles/PMC5915270/ /pubmed/29689052 http://dx.doi.org/10.1371/journal.pbio.2005894 Text en © 2018 Richards Stephen http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Primer
Richards, Stephen
Full disclosure: Genome assembly is still hard
title Full disclosure: Genome assembly is still hard
title_full Full disclosure: Genome assembly is still hard
title_fullStr Full disclosure: Genome assembly is still hard
title_full_unstemmed Full disclosure: Genome assembly is still hard
title_short Full disclosure: Genome assembly is still hard
title_sort full disclosure: genome assembly is still hard
topic Primer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915270/
https://www.ncbi.nlm.nih.gov/pubmed/29689052
http://dx.doi.org/10.1371/journal.pbio.2005894
work_keys_str_mv AT richardsstephen fulldisclosuregenomeassemblyisstillhard