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Full disclosure: Genome assembly is still hard
Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915270/ https://www.ncbi.nlm.nih.gov/pubmed/29689052 http://dx.doi.org/10.1371/journal.pbio.2005894 |
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author | Richards, Stephen |
author_facet | Richards, Stephen |
author_sort | Richards, Stephen |
collection | PubMed |
description | Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies—especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics. |
format | Online Article Text |
id | pubmed-5915270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-59152702018-05-11 Full disclosure: Genome assembly is still hard Richards, Stephen PLoS Biol Primer Two recent papers highlight the fascinating comparative genomics of anhydrobiosis, the ability to withstand complete desiccation, in bdelloid rotifers and tardigrades. However, both groups had to openly deal with the significant difficulties of generating and interpreting short-read draft assemblies—especially challenging in microscopic species with high sequence polymorphism. These exemplars demonstrate the need to go beyond single draft-quality reference genomes to high-quality multiple species comparative genomics if we are to fully capture the value of genomics. Public Library of Science 2018-04-24 /pmc/articles/PMC5915270/ /pubmed/29689052 http://dx.doi.org/10.1371/journal.pbio.2005894 Text en © 2018 Richards Stephen http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Primer Richards, Stephen Full disclosure: Genome assembly is still hard |
title | Full disclosure: Genome assembly is still hard |
title_full | Full disclosure: Genome assembly is still hard |
title_fullStr | Full disclosure: Genome assembly is still hard |
title_full_unstemmed | Full disclosure: Genome assembly is still hard |
title_short | Full disclosure: Genome assembly is still hard |
title_sort | full disclosure: genome assembly is still hard |
topic | Primer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915270/ https://www.ncbi.nlm.nih.gov/pubmed/29689052 http://dx.doi.org/10.1371/journal.pbio.2005894 |
work_keys_str_mv | AT richardsstephen fulldisclosuregenomeassemblyisstillhard |