Cargando…

Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood

Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of...

Descripción completa

Detalles Bibliográficos
Autores principales: Anderson, Emma L., Fraser, Abigail, Caleyachetty, Rishi, Hardy, Rebecca, Lawlor, Debbie A., Howe, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915314/
https://www.ncbi.nlm.nih.gov/pubmed/29102868
http://dx.doi.org/10.1016/j.chiabu.2017.10.015
_version_ 1783316844159959040
author Anderson, Emma L.
Fraser, Abigail
Caleyachetty, Rishi
Hardy, Rebecca
Lawlor, Debbie A.
Howe, Laura D.
author_facet Anderson, Emma L.
Fraser, Abigail
Caleyachetty, Rishi
Hardy, Rebecca
Lawlor, Debbie A.
Howe, Laura D.
author_sort Anderson, Emma L.
collection PubMed
description Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N = 3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood. Approximately 23 years later, body mass index (BMI), waist circumference, systolic and diastolic blood pressure, plasma glucose, insulin, triglycerides, low and high density lipoprotein cholesterol, C-reactive protein, carotid intima-media thickness (cIMT) and arterial distensibility were assessed (mean age 51 years). We examined associations of each specific type of psychosocial adversity and cumulative adversity with CVD risk factors. No specific type of psychosocial adversity was consistently associated with the CVD risk factors. There was evidence that a one standard deviation greater cumulative psychosocial adversity was associated with 0.51 cm greater waist circumference (95% confidence interval [CI]: 0.02 cm, 1.00 cm, p = 0.04) and a lower arterial distensibility, even after adjustment for age, ethnicity and childhood and adult socioeconomic position. We found no consistent evidence that any specific type of psychosocial adversity, or cumulative psychosocial adversity in childhood, is associated with CVD risk factors in adult women.
format Online
Article
Text
id pubmed-5915314
institution National Center for Biotechnology Information
language English
publishDate 2017
record_format MEDLINE/PubMed
spelling pubmed-59153142018-04-24 Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood Anderson, Emma L. Fraser, Abigail Caleyachetty, Rishi Hardy, Rebecca Lawlor, Debbie A. Howe, Laura D. Child Abuse Negl Article Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N = 3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood. Approximately 23 years later, body mass index (BMI), waist circumference, systolic and diastolic blood pressure, plasma glucose, insulin, triglycerides, low and high density lipoprotein cholesterol, C-reactive protein, carotid intima-media thickness (cIMT) and arterial distensibility were assessed (mean age 51 years). We examined associations of each specific type of psychosocial adversity and cumulative adversity with CVD risk factors. No specific type of psychosocial adversity was consistently associated with the CVD risk factors. There was evidence that a one standard deviation greater cumulative psychosocial adversity was associated with 0.51 cm greater waist circumference (95% confidence interval [CI]: 0.02 cm, 1.00 cm, p = 0.04) and a lower arterial distensibility, even after adjustment for age, ethnicity and childhood and adult socioeconomic position. We found no consistent evidence that any specific type of psychosocial adversity, or cumulative psychosocial adversity in childhood, is associated with CVD risk factors in adult women. 2017-11-02 2018-02 /pmc/articles/PMC5915314/ /pubmed/29102868 http://dx.doi.org/10.1016/j.chiabu.2017.10.015 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Anderson, Emma L.
Fraser, Abigail
Caleyachetty, Rishi
Hardy, Rebecca
Lawlor, Debbie A.
Howe, Laura D.
Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title_full Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title_fullStr Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title_full_unstemmed Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title_short Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
title_sort associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915314/
https://www.ncbi.nlm.nih.gov/pubmed/29102868
http://dx.doi.org/10.1016/j.chiabu.2017.10.015
work_keys_str_mv AT andersonemmal associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood
AT fraserabigail associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood
AT caleyachettyrishi associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood
AT hardyrebecca associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood
AT lawlordebbiea associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood
AT howelaurad associationsofadversityinchildhoodandriskfactorsforcardiovasculardiseaseinmidadulthood