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Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Detection of cardiomyocyte death is crucial for the diagnosis and treatment of heart disease. Here we use comparative methylome analysis to identify genomic loci that are unmethylated specifically in cardiomyocytes, and develop these as biomarkers to quantify cardiomyocyte DNA in circulating cell-fr...

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Detalles Bibliográficos
Autores principales:	Zemmour, Hai, Planer, David, Magenheim, Judith, Moss, Joshua, Neiman, Daniel, Gilon, Dan, Korach, Amit, Glaser, Benjamin, Shemer, Ruth, Landesberg, Giora, Dor, Yuval
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915384/ https://www.ncbi.nlm.nih.gov/pubmed/29691397 http://dx.doi.org/10.1038/s41467-018-03961-y

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