The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Acute Myeloid Leukemia (AML) with MLL gene rearrangements demonstrate unique gene expression profiles driven by MLL-fusion proteins. Here, we identify the circadian clock transcription factor SHARP1 as a novel oncogenic target in MLL-AF6 AML, which has the worst prognosis among all subtypes of MLL-r...

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Detalles Bibliográficos
Autores principales: Numata, Akihiko, Kwok, Hui Si, Kawasaki, Akira, Li, Jia, Zhou, Qi-Ling, Kerry, Jon, Benoukraf, Touati, Bararia, Deepak, Li, Feng, Ballabio, Erica, Tapia, Marta, Deshpande, Aniruddha J., Welner, Robert S., Delwel, Ruud, Yang, Henry, Milne, Thomas A., Taneja, Reshma, Tenen, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915391/
https://www.ncbi.nlm.nih.gov/pubmed/29692408
http://dx.doi.org/10.1038/s41467-018-03854-0

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