Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ). Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine...

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Detalles Bibliográficos
Autores principales: Zhang, Yongjie, den Braver-Sewradj, Shalenie P., den Braver, Michiel W., Hiemstra, Steven, Vermeulen, Nico P. E., van de Water, Bob, Commandeur, Jan N. M., Vos, J. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915463/
https://www.ncbi.nlm.nih.gov/pubmed/29720942
http://dx.doi.org/10.3389/fphar.2018.00388

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