Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection

The emergence of >300 serovars of Leptospira confounded the use of generalized bacterin, the whole cell lysate, as vaccines to control leptospirosis. Because of substantial genetic and geographic heterogeneity among circulating serovars, one vaccine strain per serovar cannot be efficacious agains...

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Detalles Bibliográficos
Autores principales: Raja, Veerapandian, Sobana, Sankaran, Mercy, Charles Solomon Akino, Cotto, Bianca, Bora, Durlav Prasad, Natarajaseenivasan, Kalimuthusamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915591/
https://www.ncbi.nlm.nih.gov/pubmed/29691454
http://dx.doi.org/10.1038/s41598-018-24674-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915591/
https://www.ncbi.nlm.nih.gov/pubmed/29691454
http://dx.doi.org/10.1038/s41598-018-24674-8

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