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Heterologous DNA prime-protein boost immunization with RecA and FliD offers cross-clade protection against leptospiral infection
The emergence of >300 serovars of Leptospira confounded the use of generalized bacterin, the whole cell lysate, as vaccines to control leptospirosis. Because of substantial genetic and geographic heterogeneity among circulating serovars, one vaccine strain per serovar cannot be efficacious agains...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915591/ https://www.ncbi.nlm.nih.gov/pubmed/29691454 http://dx.doi.org/10.1038/s41598-018-24674-8 |