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Structural basis for the activation of acid ceramidase

Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase leads to Farber disease, spinal muscular atrophy with progressive myoclonic epilepsy, and is associated with Al...

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Detalles Bibliográficos
Autores principales:	Gebai, Ahmad, Gorelik, Alexei, Li, Zixian, Illes, Katalin, Nagar, Bhushan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915598/ https://www.ncbi.nlm.nih.gov/pubmed/29692406 http://dx.doi.org/10.1038/s41467-018-03844-2

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