Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which Trk...

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Detalles Bibliográficos
Autores principales: Dhandapani, Rahul, Arokiaraj, Cynthia Mary, Taberner, Francisco J., Pacifico, Paola, Raja, Sruthi, Nocchi, Linda, Portulano, Carla, Franciosa, Federica, Maffei, Mariano, Hussain, Ahmad Fawzi, de Castro Reis, Fernanda, Reymond, Luc, Perlas, Emerald, Garcovich, Simone, Barth, Stefan, Johnsson, Kai, Lechner, Stefan G., Heppenstall, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915601/
https://www.ncbi.nlm.nih.gov/pubmed/29691410
http://dx.doi.org/10.1038/s41467-018-04049-3

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