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Phase I/II evaluation of RV1001, a novel PI3Kδ inhibitor, in spontaneous canine lymphoma

BACKGROUND: RV1001 is a novel, potent, and selective PI3Kδ inhibitor. The purpose of this study was to evaluate the safety and efficacy of RV1001 in canine Non-Hodgkin lymphoma (NHL). METHODS AND RESULTS: Inhibition of endogenous pAKT by RV1001 in primary canine NHL cells was determined by Western b...

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Detalles Bibliográficos
Autores principales:	Gardner, Heather L., Rippy, Sarah B., Bear, Misty D., Cronin, Kim L., Heeb, Heather, Burr, Holly, Cannon, Claire M., Penmetsa, Kumar V., Viswanadha, Srikant, Vakkalanka, Swaroop, London, Cheryl A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915681/ https://www.ncbi.nlm.nih.gov/pubmed/29689086 http://dx.doi.org/10.1371/journal.pone.0195357

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