Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli

Although the TEM-1 β-lactamase (Bla(TEM-1)) hydrolyzes penicillins and narrow-spectrum cephalosporins, organisms expressing this enzyme are typically susceptible to β-lactam/β-lactamase inhibitor combinations such as piperacillin-tazobactam (TZP). However, our previous work led to the discovery of 2...

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Detalles Bibliográficos
Autores principales: Schechter, Lisa M., Creely, David P., Garner, Cherilyn D., Shortridge, Dee, Nguyen, Hoan, Chen, Lei, Hanson, Blake M., Sodergren, Erica, Weinstock, George M., Dunne, W. Michael, van Belkum, Alex, Leopold, Shana R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915731/
https://www.ncbi.nlm.nih.gov/pubmed/29691340
http://dx.doi.org/10.1128/mBio.00583-18

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