Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent

The first example of copper-catalyzed direct formylation of alkenyl C–H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl(2) is expected to be developed as...

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Autores principales: Bao, Yan, Wang, Gao-Yin, Zhang, Ya-Xuan, Bian, Kang-Jie, Wang, Xi-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915796/
https://www.ncbi.nlm.nih.gov/pubmed/29732081
http://dx.doi.org/10.1039/c8sc00210j
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author Bao, Yan
Wang, Gao-Yin
Zhang, Ya-Xuan
Bian, Kang-Jie
Wang, Xi-Sheng
author_facet Bao, Yan
Wang, Gao-Yin
Zhang, Ya-Xuan
Bian, Kang-Jie
Wang, Xi-Sheng
author_sort Bao, Yan
collection PubMed
description The first example of copper-catalyzed direct formylation of alkenyl C–H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl(2) is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis.
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spelling pubmed-59157962018-05-04 Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent Bao, Yan Wang, Gao-Yin Zhang, Ya-Xuan Bian, Kang-Jie Wang, Xi-Sheng Chem Sci Chemistry The first example of copper-catalyzed direct formylation of alkenyl C–H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl(2) is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis. Royal Society of Chemistry 2018-02-14 /pmc/articles/PMC5915796/ /pubmed/29732081 http://dx.doi.org/10.1039/c8sc00210j Text en This journal is © The Royal Society of Chemistry 2018 https://creativecommons.org/licenses/by/3.0/This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Bao, Yan
Wang, Gao-Yin
Zhang, Ya-Xuan
Bian, Kang-Jie
Wang, Xi-Sheng
Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title_full Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title_fullStr Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title_full_unstemmed Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title_short Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl(2) as a stoichiometric formylating reagent
title_sort copper-catalyzed formylation of alkenyl c–h bonds using brchcl(2) as a stoichiometric formylating reagent
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915796/
https://www.ncbi.nlm.nih.gov/pubmed/29732081
http://dx.doi.org/10.1039/c8sc00210j
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