Cargando…

Parenting stress and DNA methylation among African Americans in the InterGEN Study

INTRODUCTION: General life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting s...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, Michelle L., Huang, Yunfeng, Hui, Qin, Newhall, Kevin, Crusto, Cindy, Sun, Yan V., Taylor, Jacquelyn Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915805/
https://www.ncbi.nlm.nih.gov/pubmed/29707254
http://dx.doi.org/10.1017/cts.2018.3
_version_ 1783316928004096000
author Wright, Michelle L.
Huang, Yunfeng
Hui, Qin
Newhall, Kevin
Crusto, Cindy
Sun, Yan V.
Taylor, Jacquelyn Y.
author_facet Wright, Michelle L.
Huang, Yunfeng
Hui, Qin
Newhall, Kevin
Crusto, Cindy
Sun, Yan V.
Taylor, Jacquelyn Y.
author_sort Wright, Michelle L.
collection PubMed
description INTRODUCTION: General life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother-child dyads. METHODS: We evaluated epigenome-wide DNA methylation relative to parenting stress in 74 mother-child dyads using linear mixed models. RESULTS: Significant variation in maternal DNA methylation at 95 CpG sites was associated with level of parenting stress. Notably, we identified a change in DNA methylation associated with poly (ADP-ribose) polymerase-1, which plays a key role in stress signaling. We did not identify any significant variation in child DNA methylation related to maternal parenting stress. CONCLUSIONS: However, DNA methylation patterns observed in children mirrored patterns observed in their mothers. The results suggest that differential maternal DNA methylation is associated with higher levels of parenting stress.
format Online
Article
Text
id pubmed-5915805
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-59158052018-04-27 Parenting stress and DNA methylation among African Americans in the InterGEN Study Wright, Michelle L. Huang, Yunfeng Hui, Qin Newhall, Kevin Crusto, Cindy Sun, Yan V. Taylor, Jacquelyn Y. J Clin Transl Sci Basic Translational Research INTRODUCTION: General life stress has been associated with altered DNA methylation in individuals of African Ancestry, although the relationship between parenting stress and DNA methylation has not been described. The purpose of this study was to examine the relationship between maternal parenting stress and DNA methylation among African Ancestry mother-child dyads. METHODS: We evaluated epigenome-wide DNA methylation relative to parenting stress in 74 mother-child dyads using linear mixed models. RESULTS: Significant variation in maternal DNA methylation at 95 CpG sites was associated with level of parenting stress. Notably, we identified a change in DNA methylation associated with poly (ADP-ribose) polymerase-1, which plays a key role in stress signaling. We did not identify any significant variation in child DNA methylation related to maternal parenting stress. CONCLUSIONS: However, DNA methylation patterns observed in children mirrored patterns observed in their mothers. The results suggest that differential maternal DNA methylation is associated with higher levels of parenting stress. Cambridge University Press 2018-03-12 /pmc/articles/PMC5915805/ /pubmed/29707254 http://dx.doi.org/10.1017/cts.2018.3 Text en © The Association for Clinical and Translational Science 2018 http://creativecommons.org/licenses/by-ncnd/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution-Non Commercial-NoDerivatives licence (http://creativecommons.org/licenses/by-ncnd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
spellingShingle Basic Translational Research
Wright, Michelle L.
Huang, Yunfeng
Hui, Qin
Newhall, Kevin
Crusto, Cindy
Sun, Yan V.
Taylor, Jacquelyn Y.
Parenting stress and DNA methylation among African Americans in the InterGEN Study
title Parenting stress and DNA methylation among African Americans in the InterGEN Study
title_full Parenting stress and DNA methylation among African Americans in the InterGEN Study
title_fullStr Parenting stress and DNA methylation among African Americans in the InterGEN Study
title_full_unstemmed Parenting stress and DNA methylation among African Americans in the InterGEN Study
title_short Parenting stress and DNA methylation among African Americans in the InterGEN Study
title_sort parenting stress and dna methylation among african americans in the intergen study
topic Basic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915805/
https://www.ncbi.nlm.nih.gov/pubmed/29707254
http://dx.doi.org/10.1017/cts.2018.3
work_keys_str_mv AT wrightmichellel parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT huangyunfeng parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT huiqin parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT newhallkevin parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT crustocindy parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT sunyanv parentingstressanddnamethylationamongafricanamericansintheintergenstudy
AT taylorjacquelyny parentingstressanddnamethylationamongafricanamericansintheintergenstudy