Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome

AIMS: Loss-of-function of the cardiac sodium channel Na(V)1.5 is a common feature of Brugada syndrome. Arrhythmias arise preferentially from the right ventricle (RV) despite equivalent Na(V)1.5 downregulation in the left ventricle (LV). The reasons for increased RV sensitivity to Na(V)1.5 loss-of-fu...

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Detalles Bibliográficos
Autores principales: Kelly, Allen, Salerno, Simona, Connolly, Adam, Bishop, Martin, Charpentier, Flavien, Stølen, Tomas, Smith, Godfrey L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915948/
https://www.ncbi.nlm.nih.gov/pubmed/29267949
http://dx.doi.org/10.1093/cvr/cvx244

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