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Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks
Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the hypothalamic–pituitary–adr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Endocrine Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915959/ https://www.ncbi.nlm.nih.gov/pubmed/29713692 http://dx.doi.org/10.1210/js.2018-00021 |
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author | Son, Gi Hoon Cha, Hyo Kyeong Chung, Sooyoung Kim, Kyungjin |
author_facet | Son, Gi Hoon Cha, Hyo Kyeong Chung, Sooyoung Kim, Kyungjin |
author_sort | Son, Gi Hoon |
collection | PubMed |
description | Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the hypothalamic–pituitary–adrenal axis, whereas circulating GC levels in unstressed states follow a robust circadian oscillation with a peak around the onset of the active period of a day. A recent advance in chronobiological research has revealed that multiple regulatory mechanisms, along with classical neuroendocrine regulation, underlie this GC circadian rhythm. The hierarchically organized circadian system, with a central pacemaker in the suprachiasmatic nucleus of the hypothalamus and local oscillators in peripheral tissues, including the adrenal gland, mediates periodicities in physiological processes in mammals. In this review, we primarily focus on our understanding of the circadian regulation of adrenal GC rhythm, with particular attention to the cooperative actions of the suprachiasmatic nucleus central and adrenal local clocks, and the clinical implications of this rhythm in human diseases. |
format | Online Article Text |
id | pubmed-5915959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Endocrine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-59159592018-04-30 Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks Son, Gi Hoon Cha, Hyo Kyeong Chung, Sooyoung Kim, Kyungjin J Endocr Soc Mini-Review Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the hypothalamic–pituitary–adrenal axis, whereas circulating GC levels in unstressed states follow a robust circadian oscillation with a peak around the onset of the active period of a day. A recent advance in chronobiological research has revealed that multiple regulatory mechanisms, along with classical neuroendocrine regulation, underlie this GC circadian rhythm. The hierarchically organized circadian system, with a central pacemaker in the suprachiasmatic nucleus of the hypothalamus and local oscillators in peripheral tissues, including the adrenal gland, mediates periodicities in physiological processes in mammals. In this review, we primarily focus on our understanding of the circadian regulation of adrenal GC rhythm, with particular attention to the cooperative actions of the suprachiasmatic nucleus central and adrenal local clocks, and the clinical implications of this rhythm in human diseases. Endocrine Society 2018-04-06 /pmc/articles/PMC5915959/ /pubmed/29713692 http://dx.doi.org/10.1210/js.2018-00021 Text en Copyright © 2018 Endocrine Society https://creativecommons.org/licenses/by-nc-nd/4.0/ This article has been published under the terms of the Creative Commons Attribution Non-Commercial, No-Derivatives License (CC BY-NC-ND; https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Mini-Review Son, Gi Hoon Cha, Hyo Kyeong Chung, Sooyoung Kim, Kyungjin Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title | Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title_full | Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title_fullStr | Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title_full_unstemmed | Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title_short | Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks |
title_sort | multimodal regulation of circadian glucocorticoid rhythm by central and adrenal clocks |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915959/ https://www.ncbi.nlm.nih.gov/pubmed/29713692 http://dx.doi.org/10.1210/js.2018-00021 |
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