Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus

Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically abla...

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Detalles Bibliográficos
Autores principales: Kolata, Stefan M, Nakao, Kazuhito, Jeevakumar, Vivek, Farmer-Alroth, Emily L, Fujita, Yuko, Bartley, Aundrea F, Jiang, Sunny Zhihong, Rompala, Gregory R, Sorge, Robert E, Jimenez, Dennisse V, Martinowich, Keri, Mateo, Yolanda, Hashimoto, Kenji, Dobrunz, Lynn E, Nakazawa, Kazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916365/
https://www.ncbi.nlm.nih.gov/pubmed/29362511
http://dx.doi.org/10.1038/npp.2017.296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916365/
https://www.ncbi.nlm.nih.gov/pubmed/29362511
http://dx.doi.org/10.1038/npp.2017.296

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