Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo

In T lymphocytes, expression of miR-148a is induced by T-bet and Twist1, and is specific for pro-inflammatory Th1 cells. In these cells, miR-148a inhibits the expression of the pro-apoptotic protein Bim and promotes their survival. Here we use sequence-specific cholesterol-modified oligonucleotides...

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Detalles Bibliográficos
Autores principales: Maschmeyer, Patrick, Petkau, Georg, Siracusa, Francesco, Zimmermann, Jakob, Zügel, Franziska, Kühl, Anja Andrea, Lehmann, Katrin, Schimmelpfennig, Sarah, Weber, Melanie, Haftmann, Claudia, Riedel, René, Bardua, Markus, Heinz, Gitta Anne, Tran, Cam Loan, Hoyer, Bimba Franziska, Hiepe, Falk, Herzog, Sebastian, Wittmann, Jürgen, Rajewsky, Nikolaus, Melchers, Fritz Georg, Chang, Hyun-Dong, Radbruch, Andreas, Mashreghi, Mir-Farzin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916452/
https://www.ncbi.nlm.nih.gov/pubmed/29183643
http://dx.doi.org/10.1016/j.jaut.2017.11.005

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