Cargando…

FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis

BACKGROUND: Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This study aimed to determine whether farnesyl transfer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ponnusamy, Arvind, Sinha, Smeeta, Hyde, Gareth D., Borland, Samantha J., Taylor, Rebecca F., Pond, Emma, Eyre, Heather J., Inkson, Colette A., Gilmore, Andrew, Ashton, Nick, Kalra, Philip A., Canfield, Ann E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916518/ https://www.ncbi.nlm.nih.gov/pubmed/29689070 http://dx.doi.org/10.1371/journal.pone.0196232

Ejemplares similares

Regulation of vascular smooth muscle cell calcification by syndecan-4/FGF-2/PKCα signalling and cross-talk with TGFβ
por: Borland, Samantha J., et al.
Publicado: (2017)

Ras Farnesylation Inhibitor FTI‐277 Restores the E‐Cadherin/Catenin Cell Adhesion System in Human Cancer Cells and Reduces Cancer Metastasis
por: Nam, Jeong‐Seok, et al.
Publicado: (2002)

Axl Tyrosine Kinase Protects against Tubulo-Interstitial Apoptosis and Progression of Renal Failure in a Murine Model of Chronic Kidney Disease and Hyperphosphataemia
por: Hyde, Gareth D., et al.
Publicado: (2014)

FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
por: Tonelli, Francesca, et al.
Publicado: (2010)

New FTY720-docetaxel nanoparticle therapy overcomes FTY720-induced lymphopenia and inhibits metastatic breast tumour growth
por: Alshaker, Heba, et al.
Publicado: (2017)

Native and transplant kidney histopathological manifestations in association with COVID-19 infection: A systematic review
por: Jeyalan, Vishnu, et al.
Publicado: (2021)

FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
por: Yu, Hong, et al.
Publicado: (2015)

FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
por: Szymiczek, Agata, et al.
Publicado: (2017)

FTY720-derivatives do not induce FTY720-like lymphopenia
por: Segura-Ulate, Ismael, et al.
Publicado: (2017)

X-ray Micro-Computed Tomography: An Emerging Technology to Analyze Vascular Calcification in Animal Models
por: Borland, Samantha J., et al.
Publicado: (2020)

Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells
por: Zavaczki, Erzsébet, et al.
Publicado: (2011)

ZNF277 regulates ovarian cancer cell proliferation and invasion through inhibition of PTEN
por: Liu, Zhengling, et al.
Publicado: (2019)

Arterial Klotho Expression and FGF23 Effects on Vascular Calcification and Function
por: Lindberg, Karolina, et al.
Publicado: (2013)

Health Tract, No. 277: The Tomatoe
Publicado: (1867)

FTY720 elevates smooth muscle contraction of aorta and blood pressure in rats via ERK activation
por: Zhao, Zhen, et al.
Publicado: (2017)

FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling
por: Lu, Zhaoyang, et al.
Publicado: (2014)

FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines
por: Su, Ke, et al.
Publicado: (2017)

AGEs-Induced Calcification and Apoptosis in Human Vascular Smooth Muscle Cells Is Reversed by Inhibition of Autophagy
por: He, Hu-Qiang, et al.
Publicado: (2021)

FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition
por: Ryu, Jaeyoon, et al.
Publicado: (2020)

FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation
por: Hirata, Naoya, et al.
Publicado: (2021)

FTY720 Inhibits the Development of Collagen-Induced Arthritis in Mice by Suppressing the Recruitment of CD4(+) T Lymphocytes
por: Zhu, Chao, et al.
Publicado: (2021)

Analogs of FTY720 inhibit TRPM7 but not S1PRs and exert multimodal anti-inflammatory effects
por: Busey, Gregory W., et al.
Publicado: (2023)

FTY720 attenuates excitotoxicity and neuroinflammation
por: Cipriani, Raffaela, et al.
Publicado: (2015)

201909-277 OpenDays ME-31
por: Ordan, Julien Marius, et al.
Publicado: (2019)

MicroRNA-223-3p inhibits vascular calcification and the osteogenic switch of vascular smooth muscle cells
por: Han, Yingchun, et al.
Publicado: (2021)

Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1
por: Zhang, Tianran, et al.
Publicado: (2020)

Kv1.3 Channel Inhibition Limits Uremia-Induced Calcification in Mouse and Human Vascular Smooth Muscle
por: Cazaña-Pérez, Violeta, et al.
Publicado: (2020)

Inhibition of the Semaphorin 4D-Plexin-B1 axis prevents calcification in vascular smooth muscle cells
por: Park, Hyun-Joo, et al.
Publicado: (2023)

SARS-CoV-2 antibody screening in healthcare workers in a tertiary centre in North West England
por: Poulikakos, Dimitrios, et al.
Publicado: (2020)

Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade
por: Martin, Janet L., et al.
Publicado: (2017)

Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling
por: Willems, Brecht A., et al.
Publicado: (2018)

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells
por: Lee, Ki Mo, et al.
Publicado: (2017)

RTEF-1 Inhibits Vascular Smooth Muscle Cell Calcification through Regulating Wnt/β-Catenin Signaling Pathway
por: Cong, Jingjing, et al.
Publicado: (2021)

Drosophila Myc restores immune homeostasis of Imd pathway via activating miR-277 to inhibit imd/Tab2
por: Li, Ruimin, et al.
Publicado: (2020)

277 Molecular Epidemiology of Staphyloccocus aureus in Children with Bacteremia
por: Al-Zubeidi, Duha, et al.
Publicado: (2014)

SUN-277 Severe Hyperglycemia in the Setting of Hypernatremic Dehydration
por: Gupta, Meenal, et al.
Publicado: (2019)

SAT-277 A Fierce Presentation of Cushing Disease
por: Al Sabie, Farah Laith, et al.
Publicado: (2020)

FTY720-induced endocytosis of yeast and human amino acid transporters is preceded by reduction of their inherent activity and TORC1 inhibition
por: Barthelemy, Céline, et al.
Publicado: (2017)

The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod
por: Patmanathan, Sathya Narayanan, et al.
Publicado: (2015)

The emerging role of FTY720 (Fingolimod) in cancer treatment
por: White, Christopher, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_23j8je8a5hiet2nhjs1pn59h78