Cargando…

Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia

PURPOSE: Retinal image quality is dependent on accommodative performance. This longitudinal observational study of children with unilateral amblyopia evaluated the accommodative performance of the amblyopic eye during treatment. METHODS: Twenty-six participants with unilateral amblyopia and 10 parti...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Angela M., Manh, Vivian, Candy, T. Rowan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916545/
https://www.ncbi.nlm.nih.gov/pubmed/29801152
http://dx.doi.org/10.1167/iovs.17-22990
_version_ 1783317030220333056
author Chen, Angela M.
Manh, Vivian
Candy, T. Rowan
author_facet Chen, Angela M.
Manh, Vivian
Candy, T. Rowan
author_sort Chen, Angela M.
collection PubMed
description PURPOSE: Retinal image quality is dependent on accommodative performance. This longitudinal observational study of children with unilateral amblyopia evaluated the accommodative performance of the amblyopic eye during treatment. METHODS: Twenty-six participants with unilateral amblyopia and 10 participants with typical vision aged 3 to 10 years participated. Accommodative response was measured using modified Nott retinoscopy in monocular and binocular viewing conditions for target distances of 50, 33, and 25 cm, at enrollment and each follow-up visit. RESULTS: Participants with amblyopia accommodated less accurately when viewing with their amblyopic eye in monocular than in binocular conditions. Over the course of amblyopia treatment, accommodative performance improved with amblyopic eye visual acuity (VA) improvement, although this was not consistent across individual participants. A linear mixed model showed that accommodative error worsened with increasing depth of amblyopia for monocular viewing with the amblyopic eye (0.14 diopter [D] per line of acuity loss, P = 0.001), with an interaction between VA and stimulus demand (0.09 D of additional lag per diopter of stimulus, per line of acuity loss, P < 0.001). Participant age, patching duration, length of time in the study, history of strabismus, and stereoacuity were not significant predictors of accommodative performance. CONCLUSIONS: Overall, poor monocular accommodative performance of the amblyopic eye was associated with worse amblyopia and improved simultaneously with VA improvement, although there was variability across the study cohort. Further research is needed to determine the causal relationship between amblyopic eye VA and accommodation and its impact on amblyopia treatment.
format Online
Article
Text
id pubmed-5916545
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher The Association for Research in Vision and Ophthalmology
record_format MEDLINE/PubMed
spelling pubmed-59165452018-04-27 Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia Chen, Angela M. Manh, Vivian Candy, T. Rowan Invest Ophthalmol Vis Sci Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology PURPOSE: Retinal image quality is dependent on accommodative performance. This longitudinal observational study of children with unilateral amblyopia evaluated the accommodative performance of the amblyopic eye during treatment. METHODS: Twenty-six participants with unilateral amblyopia and 10 participants with typical vision aged 3 to 10 years participated. Accommodative response was measured using modified Nott retinoscopy in monocular and binocular viewing conditions for target distances of 50, 33, and 25 cm, at enrollment and each follow-up visit. RESULTS: Participants with amblyopia accommodated less accurately when viewing with their amblyopic eye in monocular than in binocular conditions. Over the course of amblyopia treatment, accommodative performance improved with amblyopic eye visual acuity (VA) improvement, although this was not consistent across individual participants. A linear mixed model showed that accommodative error worsened with increasing depth of amblyopia for monocular viewing with the amblyopic eye (0.14 diopter [D] per line of acuity loss, P = 0.001), with an interaction between VA and stimulus demand (0.09 D of additional lag per diopter of stimulus, per line of acuity loss, P < 0.001). Participant age, patching duration, length of time in the study, history of strabismus, and stereoacuity were not significant predictors of accommodative performance. CONCLUSIONS: Overall, poor monocular accommodative performance of the amblyopic eye was associated with worse amblyopia and improved simultaneously with VA improvement, although there was variability across the study cohort. Further research is needed to determine the causal relationship between amblyopic eye VA and accommodation and its impact on amblyopia treatment. The Association for Research in Vision and Ophthalmology 2018-04 /pmc/articles/PMC5916545/ /pubmed/29801152 http://dx.doi.org/10.1167/iovs.17-22990 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
Chen, Angela M.
Manh, Vivian
Candy, T. Rowan
Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title_full Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title_fullStr Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title_full_unstemmed Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title_short Longitudinal Evaluation of Accommodation During Treatment for Unilateral Amblyopia
title_sort longitudinal evaluation of accommodation during treatment for unilateral amblyopia
topic Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916545/
https://www.ncbi.nlm.nih.gov/pubmed/29801152
http://dx.doi.org/10.1167/iovs.17-22990
work_keys_str_mv AT chenangelam longitudinalevaluationofaccommodationduringtreatmentforunilateralamblyopia
AT manhvivian longitudinalevaluationofaccommodationduringtreatmentforunilateralamblyopia
AT candytrowan longitudinalevaluationofaccommodationduringtreatmentforunilateralamblyopia