A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library

Deep sequencing and single-chain variable fragment (scFv) yeast display methods are becoming more popular for discovery of therapeutic antibody candidates in mouse B cell repertoires. In this study, we compare a deep sequencing and scFv display method that retains native heavy and light chain pairin...

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Detalles Bibliográficos
Autores principales: Adler, Adam S., Bedinger, Daniel, Adams, Matthew S., Asensio, Michael A., Edgar, Robert C., Leong, Renee, Leong, Jackson, Mizrahi, Rena A., Spindler, Matthew J., Bandi, Srinivasa Rao, Huang, Haichun, Tawde, Pallavi, Brams, Peter, Johnson, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916548/
https://www.ncbi.nlm.nih.gov/pubmed/29376776
http://dx.doi.org/10.1080/19420862.2018.1426422

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