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Mild hypothermic culture conditions affect residual host cell protein composition post-Protein A chromatography
Host cell proteins (HCPs) are endogenous impurities, and their proteolytic and binding properties can compromise the integrity, and, hence, the stability and efficacy of recombinant therapeutic proteins such as monoclonal antibodies (mAbs). Nonetheless, purification of mAbs currently presents a chal...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916555/ https://www.ncbi.nlm.nih.gov/pubmed/29381421 http://dx.doi.org/10.1080/19420862.2018.1433977 |