A novel bicistronic gene design couples stable cell line selection with a fucose switch in a designer CHO host to produce native and afucosylated glycoform antibodies

The conserved glycosylation site Asn(297) of a monoclonal antibody (mAb) can be decorated with a variety of sugars that can alter mAb pharmacokinetics and recruitment of effector proteins. Antibodies lacking the core fucose at Asn(297) (afucosylated mAbs) show enhanced antibody-dependent cell-mediat...

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Detalles Bibliográficos
Autores principales: Roy, Gargi, Martin, Tom, Barnes, Arnita, Wang, Jihong, Jimenez, Rod Brian, Rice, Megan, Li, Lina, Feng, Hui, Zhang, Shu, Chaerkady, Raghothama, Wu, Herren, Marelli, Marcello, Hatton, Diane, Zhu, Jie, Bowen, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916560/
https://www.ncbi.nlm.nih.gov/pubmed/29400603
http://dx.doi.org/10.1080/19420862.2018.1433975

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